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<p>Since 2022, a decrease in egg production and hatchability, along with hepatitis-like symptoms, has been frequently reported in Muscovy duck farms in southern China. Using metagenomic sequencing, a novel Chaphamaparvovirus (ChPV), designated MuChPV-GD2022, was detected in the livers of the diseased ducks. Phylogenetic analysis revealed that the MuChPV-GD2022 strain shares 61.8–77.4% genome identity with duck-origin Chaphamaparvoviruses, and 44.3–77.4% with avian-origin Chaphamaparvoviruses. The NS1 protein amino acid sequence showed a 29.3–71.5% similarity to those of other known Chaphamaparvoviruses. These findings support the classification of MuChPV-GD2022 as a new species in the genus <i>Chaphamaparvovirus</i>, family <i>Parvoviridae</i>. Since virus isolation was not achieved due to technical constraints, the evidence suggests MuChPV may be associated with the hepatitis-like disease. Furthermore, a TaqMan qPCR assay targeting NS1 gene of the virus was developed and validated for specificity, sensitivity, and repeatability, which provides a sensitive tool not only for virus detection but also for epidemiological surveillance of MuChPV infections.</p>

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A novel Chaphamaparvovirus detected in breeding Muscovy Ducks with hepatitis

  • 期刊论文

  • 发表日期：

    2026年7月28日

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  • Yadong Gao,
  • Jiawen Dong,
  • Ouyang Peng,
  • Zhuanqiang Yan,
  • Meiting Chen,
  • Yingshan Yin,
  • Minhua Sun,
  • Junqin Zhang,
  • Yunzhen Huang,
  • Yong Xiang,
  • Zhai Qi,
  • Junwei Ge,
  • Limei Qin,
  • Linlin Li,
  • Yun Zhang

摘要

Since 2022, a decrease in egg production and hatchability, along with hepatitis-like symptoms, has been frequently reported in Muscovy duck farms in southern China. Using metagenomic sequencing, a novel Chaphamaparvovirus (ChPV), designated MuChPV-GD2022, was detected in the livers of the diseased ducks. Phylogenetic analysis revealed that the MuChPV-GD2022 strain shares 61.8–77.4% genome identity with duck-origin Chaphamaparvoviruses, and 44.3–77.4% with avian-origin Chaphamaparvoviruses. The NS1 protein amino acid sequence showed a 29.3–71.5% similarity to those of other known Chaphamaparvoviruses. These findings support the classification of MuChPV-GD2022 as a new species in the genus Chaphamaparvovirus, family Parvoviridae. Since virus isolation was not achieved due to technical constraints, the evidence suggests MuChPV may be associated with the hepatitis-like disease. Furthermore, a TaqMan qPCR assay targeting NS1 gene of the virus was developed and validated for specificity, sensitivity, and repeatability, which provides a sensitive tool not only for virus detection but also for epidemiological surveillance of MuChPV infections.