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<p>Amyloid A (AA) amyloidosis is a progressive disease caused by the deposition of AA, an abnormally folded protein derived from serum amyloid A (SAA), in organs throughout the body. AA amyloidosis occurs in various mammals and birds but is extremely rare in commercial pigs. A possible reason for this is that a variant SAA is crucial for the onset of AA amyloidosis in pigs. However, AA amyloidosis with wild-type SAA was recently reported in microminipigs, which are the smallest laboratory pigs, leaving the importance of this variant unclear. This is a report of the involvement of wild-type SAA in AA amyloidosis in 4-month-old three-way crossed pigs (Landrace, Large White, and Duroc: LWD). Using immunohistochemistry, transmission electron microscopy, mass spectrometry, and DNA sequencing, we determined that the amyloid fibrils were derived from wild-type SAA without detectable variant, which is a rare finding in commercial pigs. This finding suggests that AA amyloidosis can occur in commercial pigs regardless of the presence of the SAA variant.</p>

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Amyloid A amyloidosis associated with Streptococcus suis infection in a young commercial pig with wild-type serum amyloid A

  • 期刊论文

  • 发表日期：

    2025年12月9日

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  • Susumu Iwaide,
  • Hayate Nishiura,
  • Natsumi Kobayashi,
  • Tomoaki Murakami,
  • Yoshiyuki Itoh,
  • Kumiko Kimura,
  • Ayako Okada,
  • Yuko Tsuka,
  • Shoya Takaki,
  • Tomoyuki Shibahara

摘要

Amyloid A (AA) amyloidosis is a progressive disease caused by the deposition of AA, an abnormally folded protein derived from serum amyloid A (SAA), in organs throughout the body. AA amyloidosis occurs in various mammals and birds but is extremely rare in commercial pigs. A possible reason for this is that a variant SAA is crucial for the onset of AA amyloidosis in pigs. However, AA amyloidosis with wild-type SAA was recently reported in microminipigs, which are the smallest laboratory pigs, leaving the importance of this variant unclear. This is a report of the involvement of wild-type SAA in AA amyloidosis in 4-month-old three-way crossed pigs (Landrace, Large White, and Duroc: LWD). Using immunohistochemistry, transmission electron microscopy, mass spectrometry, and DNA sequencing, we determined that the amyloid fibrils were derived from wild-type SAA without detectable variant, which is a rare finding in commercial pigs. This finding suggests that AA amyloidosis can occur in commercial pigs regardless of the presence of the SAA variant.