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<p>Herein, we describe ocular abnormalities in an adult male Crested Capuchin (<i>Sapajus robustus)</i> with partial unilateral loss of vision. On necropsy, there was a white, firm, and homogeneous plaque expanding the ciliary body of the left eyeball. White, irregular and firm nodules were observed in skeletal muscles, lymph nodes, lungs, heart, spleen, ileum, cecum, pancreas, and testes. Microscopically, diffuse severe pyogranulomatous endophthalmitis in the left eyeball and mild granulomatous posterior uveitis in the right eyeball, both with intralesional yeasts, were noted. Immunohistochemistry revealed strong labeling with anti-<i>Paracoccidiodes</i> spp. Fungal culture and molecular examination were performed, and confirmed <i>P. brasiliensis</i> infection. Based on the marked differences in lesion severity between the two eyes, we suggest that choroidal vessels may play a crucial role in the ocular dissemination of <i>P. brasiliensis</i>.</p>

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Pyogranulomatous endophthalmitis and posterior uveitis in a crested capuchin (Sapajus robustus) with systemic Paracoccidioides brasiliensis infection

  • 期刊论文

  • 发表日期：

    2025年11月25日

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  • Asheley H. B. Pereira,
  • Fernanda C. Rocha,
  • Águida A. Oliveira,
  • Juliana M. Guerra,
  • Cinthya dos S. Cirqueira,
  • Ana C. L. Caldeira,
  • Valeria Dutra,
  • Luciano Nakazato,
  • Alcides Pissinatti,
  • Daniel G. Ubiali

摘要

Herein, we describe ocular abnormalities in an adult male Crested Capuchin (Sapajus robustus) with partial unilateral loss of vision. On necropsy, there was a white, firm, and homogeneous plaque expanding the ciliary body of the left eyeball. White, irregular and firm nodules were observed in skeletal muscles, lymph nodes, lungs, heart, spleen, ileum, cecum, pancreas, and testes. Microscopically, diffuse severe pyogranulomatous endophthalmitis in the left eyeball and mild granulomatous posterior uveitis in the right eyeball, both with intralesional yeasts, were noted. Immunohistochemistry revealed strong labeling with anti-Paracoccidiodes spp. Fungal culture and molecular examination were performed, and confirmed P. brasiliensis infection. Based on the marked differences in lesion severity between the two eyes, we suggest that choroidal vessels may play a crucial role in the ocular dissemination of P. brasiliensis.