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<p><i>Toxoplasma gondii</i> is one of the major causes of abortion in sheep in many countries. We report an episode of a novel atypical genotype of <i>T. gondii</i>-associated abortion in a sheep flock belonging to the Veterinary School Hospital of the University of Cuiabá located in Midwestern Brazil. The group of animals was comprised of 15 adult sheep, and one abortion was detected in a gestating ewe. <i>T. gondii</i> indirect immunofluorescence assay performed in serum samples yielded an antibody titer of 1:8192 in the affected dam indicating an acute phase of infection. The aborted fetus and placenta were submitted for necropsy. The only significant gross findings were the placental cotyledons with white foci. Microscopic findings included multifocal necrotizing encephalitis with intralesional protozoal cysts in the fetus’s brain and moderate multifocal lymphoplasmacytic necrotizing placentitis. Tissue samples of the fetus and placenta had a positive PCR result for <i>T. gondii</i>. Restriction fragment length polymorphism (RFLP) genotyping using markers (SAG1, 5’-SAG2, 3’-SAG2, Alt.SAG2, SAG3, BTUB, GRA6, c22-8, c29-2, L358, PK1, and APICO) was carried out and the results were consistent with an atypical genotype.</p>

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Description of a sheep abortion caused by atypical genotype of Toxoplasma gondii in the state of Mato Grosso, Brazil

  • 期刊论文

  • 发表日期：

    2025年4月25日

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  • Ícaro Guilherme dos Santos,
  • Marlon Ribeiro,
  • João Paulo da Silva Cavasani,
  • Luana Dias o Nascimento,
  • Bernardo Nassau de Souza,
  • Rafaela Mallmann-Bohn,
  • Fábio Bernardo Schein,
  • João Fabio Soares,
  • Beatriz Souza Lima Nino,
  • João Luis Garcia,
  • Daniel Felipe Barrantes Murillo,
  • Tatiane Terumi Negrão Watanabe,
  • Daniel Moura de Aguiar,
  • Caroline Argenta Pescador

摘要

Toxoplasma gondii is one of the major causes of abortion in sheep in many countries. We report an episode of a novel atypical genotype of T. gondii-associated abortion in a sheep flock belonging to the Veterinary School Hospital of the University of Cuiabá located in Midwestern Brazil. The group of animals was comprised of 15 adult sheep, and one abortion was detected in a gestating ewe. T. gondii indirect immunofluorescence assay performed in serum samples yielded an antibody titer of 1:8192 in the affected dam indicating an acute phase of infection. The aborted fetus and placenta were submitted for necropsy. The only significant gross findings were the placental cotyledons with white foci. Microscopic findings included multifocal necrotizing encephalitis with intralesional protozoal cysts in the fetus’s brain and moderate multifocal lymphoplasmacytic necrotizing placentitis. Tissue samples of the fetus and placenta had a positive PCR result for T. gondii. Restriction fragment length polymorphism (RFLP) genotyping using markers (SAG1, 5’-SAG2, 3’-SAG2, Alt.SAG2, SAG3, BTUB, GRA6, c22-8, c29-2, L358, PK1, and APICO) was carried out and the results were consistent with an atypical genotype.