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Objective <p>The efficacy of Low-intensity extracorporeal shockwave therapy (Li-ESWT) for erectile dysfunction (ED) in patients undergoing radical prostatectomy (RP) remains poorly recognized. To address this, we conducted a meta-analysis of randomized controlled trials (RCTs) to evaluate the effectiveness of this intervention.</p> Methods <p>From January 2000 to May 2025, five RCTs were selected, involving a total of 297 patients from PubMed, EMBASE, and the Cochrane Library to evaluate the efficacy of Li-ESWT for ED in patients undergoing RP.</p> Results <p>At the 8- and 12-week assessments following Li-ESWT, participants who underwent Li-ESWT demonstrated significantly greater improvements in IIEF scores compared with those in the control group (8-week: MD 2.80, P &lt; 0.0001; 12-week: MD 2.10, P = 0.004). In contrast, no significant differences in IIEF scores were detected between the Li-ESWT and control groups at 24&#xa0;weeks and beyond post-treatment.</p> Conclusion <p>Li-ESWT significantly improves short-term erectile function in patients following RP. However, this therapeutic benefit was not sustained beyond 24&#xa0;weeks. Accordingly, further research is warranted to investigate novel strategies and combination therapies aimed at preserving long-term erectile function after RP.</p>

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Systematic review and meta-analysis of randomized controlled trials: low-intensity extracorporeal shockwave therapy (Li-ESWT) for erectile dysfunction after radical prostatectomy

  • 期刊论文

  • 发表日期：

    2026年7月3日

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  • Zhongbao Zhou,
  • Zhuoqi Cheng,
  • Guangzhu Wei,
  • Yong Zhang

摘要

Objective

The efficacy of Low-intensity extracorporeal shockwave therapy (Li-ESWT) for erectile dysfunction (ED) in patients undergoing radical prostatectomy (RP) remains poorly recognized. To address this, we conducted a meta-analysis of randomized controlled trials (RCTs) to evaluate the effectiveness of this intervention.

Methods

From January 2000 to May 2025, five RCTs were selected, involving a total of 297 patients from PubMed, EMBASE, and the Cochrane Library to evaluate the efficacy of Li-ESWT for ED in patients undergoing RP.

Results

At the 8- and 12-week assessments following Li-ESWT, participants who underwent Li-ESWT demonstrated significantly greater improvements in IIEF scores compared with those in the control group (8-week: MD 2.80, P < 0.0001; 12-week: MD 2.10, P = 0.004). In contrast, no significant differences in IIEF scores were detected between the Li-ESWT and control groups at 24 weeks and beyond post-treatment.

Conclusion

Li-ESWT significantly improves short-term erectile function in patients following RP. However, this therapeutic benefit was not sustained beyond 24 weeks. Accordingly, further research is warranted to investigate novel strategies and combination therapies aimed at preserving long-term erectile function after RP.