Purpose <p>The benefits of incremental peritoneal dialysis (IPD) with days off remain controversial. This study aimed to compare the survival rate between IPD with days off and standard-dose peritoneal dialysis (PD).</p> Methods <p>Participants who started continuous peritoneal dialysis (CAPD) between October 1, 2020 and November 30, 2021, in a tertiary hospital in Thailand were enrolled. IPD with two days off (performed 5&#xa0;days a week) and standard-dose PD (performed every day) were compared using propensity score matching at a 1:1 ratio for baseline characteristics. The primary outcome was 1-year patient survival. One-year PD continuation rate, PD-associated peritonitis rate, admission rate, and weekly Kt/V at 6&#xa0;weeks, 6&#xa0;months, and 12&#xa0;months were analyzed.</p> Results <p>The 118 eligible patients (37 IPD and 81 standard-dose PD) were included. After propensity score matching, the groups were compared. One-year patient survival rates were comparable between groups, with no statistically significant difference (94.3% vs. 97.4% in the IPD and standard-dose PD groups, respectively; hazard ratio (HR) 2.15, 95% confidence interval (CI) 0.19–23.75). The 1-year PD continuation, PD-associated peritonitis rate, and admission rate were comparable between groups. Total weekly Kt/V over the 12&#xa0;months showed no significant change over time.</p> Conclusion <p>IPD with days off appears to be safe and comparable to standard-dose PD in terms of short-term patient survival.</p>