Scholarlink

Purpose <p>This study aimed to analyze the natural history and radiological progression and malignancy of Bosniak IIF renal cysts based on the 2019 version of the classification.</p> Methods <p>We conducted a single-center retrospective observational study, reviewing radiology reports from CT scans performed between March 2007 and December 2021. The final cohort included 85 patients with at least two imaging studies. Demographic, clinical, and radiological data, including cyst size, septal characteristics, and contrast-enhanced ultrasound (CEUS) findings, were analyzed. Kaplan–Meier survival analysis and Cox regression models were applied to identify potential predictors of cyst progression.</p> Results <p>During a median follow-up of 46&#xa0;months (IQR 30–71), 5 patients (6%) experienced cyst progression: 4 to Bosniak III and 1 to Bosniak IV with simultaneous detection of liver metastases. The median time to progression was 10.3&#xa0;months (IQR 9–24). Among the four surgically treated cases, histopathological analyses confirmed renal cell carcinoma in two, a multicystic nephroma in one, and a benign lesion in the remaining case. Contrast-enhanced ultrasound (CEUS) was performed in 45% of patients. On univariable analysis, larger cyst size (HR 1.02; 95% CI 1.01–1.04) and septal enhancement on CEUS (HR 12.4; 95% CI 1.28–120.7) were associated with progression.</p> Conclusion <p>The risk of malignancy in Bosniak IIF cysts remains low, with a malignancy rate of 3.5%. Lesion size appears to be associated with progression, supporting its potential role in informing follow-up strategies. The first year of surveillance seems to be particularly critical, and an early reassessment at 6&#xa0;months may facilitate the identification of lesions at higher risk of progression.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Bosniak IIF renal cysts: natural history and the impact of lesion size on progression

  • 期刊论文

  • 发表日期：

    2026年1月7日

查看全文
  • Ana Fernández-Mardomingo Díaz,
  • Alberto Artiles Medina,
  • David López Curtis,
  • César Mínguez Ojeda,
  • José Daniel Subiela,
  • Fernando González Tello,
  • Enrique Sanz Mayayo,
  • Irene De la Parra Sánchez,
  • Victoria Gómez Dos Santos,
  • Francisco Javier Burgos Revilla

摘要

Purpose

This study aimed to analyze the natural history and radiological progression and malignancy of Bosniak IIF renal cysts based on the 2019 version of the classification.

Methods

We conducted a single-center retrospective observational study, reviewing radiology reports from CT scans performed between March 2007 and December 2021. The final cohort included 85 patients with at least two imaging studies. Demographic, clinical, and radiological data, including cyst size, septal characteristics, and contrast-enhanced ultrasound (CEUS) findings, were analyzed. Kaplan–Meier survival analysis and Cox regression models were applied to identify potential predictors of cyst progression.

Results

During a median follow-up of 46 months (IQR 30–71), 5 patients (6%) experienced cyst progression: 4 to Bosniak III and 1 to Bosniak IV with simultaneous detection of liver metastases. The median time to progression was 10.3 months (IQR 9–24). Among the four surgically treated cases, histopathological analyses confirmed renal cell carcinoma in two, a multicystic nephroma in one, and a benign lesion in the remaining case. Contrast-enhanced ultrasound (CEUS) was performed in 45% of patients. On univariable analysis, larger cyst size (HR 1.02; 95% CI 1.01–1.04) and septal enhancement on CEUS (HR 12.4; 95% CI 1.28–120.7) were associated with progression.

Conclusion

The risk of malignancy in Bosniak IIF cysts remains low, with a malignancy rate of 3.5%. Lesion size appears to be associated with progression, supporting its potential role in informing follow-up strategies. The first year of surveillance seems to be particularly critical, and an early reassessment at 6 months may facilitate the identification of lesions at higher risk of progression.