Scholarlink

Objective <p>To compare the oncologic outcomes of intermediate-risk prostate cancer (FIR-PCa) patients receiving different initial treatment regimens as more FIR-PCa patients are now recommended for non-radical treatment due to the side effects of radical therapy.</p> Methods <p>8616 FIR prostate cancer patients were retrospectively evaluated using the Surveillance, Epidemiology, and End Results (SEER) database (2010–2015) and reported prostate cancer-specific survival (PCSS) for groups defined by the initial treatment category. Statistical analysis was performed using Pearson’s chi-square test, Multivariate Cox proportional hazard regression, and Kaplan–Meier method.</p> Results <p>Kaplan–Meier curves of PCSS revealed that non-curative treatment provided worse disease control than curative management for FIR-PCa patients (Hazard ratio 5.9061; 95% confidence interval 3.3398–10.4446; <i>p</i> &lt; 0.0001). After adjusting for age at diagnosis, race, T stage, PSA level, and Gleason score, non-curative management was significantly associated with a decrease in PCSS (Adjusted hazard ratio 3.34; 95% CI 1.97–5.67; <i>p</i> = 0.0027).</p> Conclusion <p>Pending prospective validation, our findings do not support a ‘uniform’ increment in current utilization practices for non-curative treatment strategies for FIR-PCa.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Initial non-curative treatment for favorable intermediate-risk prostate cancer

  • 期刊论文

  • 发表日期：

    2025年8月27日

查看全文
  • Yuanming Chen,
  • Xun Shangguan

摘要

Objective

To compare the oncologic outcomes of intermediate-risk prostate cancer (FIR-PCa) patients receiving different initial treatment regimens as more FIR-PCa patients are now recommended for non-radical treatment due to the side effects of radical therapy.

Methods

8616 FIR prostate cancer patients were retrospectively evaluated using the Surveillance, Epidemiology, and End Results (SEER) database (2010–2015) and reported prostate cancer-specific survival (PCSS) for groups defined by the initial treatment category. Statistical analysis was performed using Pearson’s chi-square test, Multivariate Cox proportional hazard regression, and Kaplan–Meier method.

Results

Kaplan–Meier curves of PCSS revealed that non-curative treatment provided worse disease control than curative management for FIR-PCa patients (Hazard ratio 5.9061; 95% confidence interval 3.3398–10.4446; p < 0.0001). After adjusting for age at diagnosis, race, T stage, PSA level, and Gleason score, non-curative management was significantly associated with a decrease in PCSS (Adjusted hazard ratio 3.34; 95% CI 1.97–5.67; p = 0.0027).

Conclusion

Pending prospective validation, our findings do not support a ‘uniform’ increment in current utilization practices for non-curative treatment strategies for FIR-PCa.