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<p>We comment on Sunsandee et al.'s RCT of leucine-enriched BCAA supplementation in elderly CKD patients. Despite a modest muscle gain, methodological and practical limitations—including unbalanced BCAA formulation, insensitive functional tests, lack of subgroup analysis, and high pill burden—undermine generalizability. Recommendations for future studies are discussed.</p>

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Comments on investigating leucine-enriched branched-chain amino acid (BCAA) supplementation in elderly chronic kidney disease (CKD) patients

  • 期刊论文

  • 发表日期：

    2025年7月14日

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  • Hussain Ramzan,
  • Imran Saeed,
  • Haseeb Naveed

摘要

We comment on Sunsandee et al.'s RCT of leucine-enriched BCAA supplementation in elderly CKD patients. Despite a modest muscle gain, methodological and practical limitations—including unbalanced BCAA formulation, insensitive functional tests, lack of subgroup analysis, and high pill burden—undermine generalizability. Recommendations for future studies are discussed.