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Purpose <p>To investigate the association between a history of kidney stones and long-term all-cause and cause-specific mortality in a nationally representative sample of US adults.</p> Methods <p>This observational study included adults who participated in the Third National Health and Nutrition Examination Survey (NHANES III, 1988–1994). Kidney stone history was self-reported during the survey. Vital status and causes of death during follow-up were ascertained via the National Death Index through December 31, 2019. Weighted Cox proportional hazards models estimated hazard ratios (HRs) for the association between kidney stone history and all-cause, cardiovascular, cancer, and renal mortality. Models were progressively adjusted for demographic, socioeconomic, and clinical variables to account for confounding factors.</p> Results <p>The final analytic sample comprised 19,578 participants (weighted kidney stone prevalence = 5.3%) with 420,947 person-years of follow-up (range: 0–31&#xa0;years). Stone formers were older than non-stone formers (mean age 54 vs. 43&#xa0;years) with a higher prevalence of comorbidities. In the unadjusted model, kidney stone history was associated with increased all-cause mortality risk (HR = 1.82; 95% CI 1.63–2.03). However, this association was attenuated in the fully adjusted model (HR = 0.89; 95% CI 0.79–1.01). No significant differences were observed between groups for cardiovascular (HR = 0.87; 95% CI 0.73–1.03), cancer (HR = 1.01; 95% CI 0.74–1.37), or renal mortality (HR = 0.99; 95% CI 0.31–3.16) in fully adjusted models.</p> Conclusion <p>In this nationally representative cohort of US adults, a history of kidney stones was not associated with an increased risk of all-cause or cause-specific mortality after adjustment for confounders.</p>

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Long-term mortality risk in US adults with a history of kidney stones: results from NHANES III with over 30 years of follow-up

  • 期刊论文

  • 发表日期：

    2025年5月8日

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  • Ben H. Chew,
  • Samir Bhattacharyya,
  • Larry E. Miller,
  • Steffi K. K. Yuen,
  • Thomas Tailly,
  • Vineet Gauhar,
  • Naeem Bhojani

摘要

Purpose

To investigate the association between a history of kidney stones and long-term all-cause and cause-specific mortality in a nationally representative sample of US adults.

Methods

This observational study included adults who participated in the Third National Health and Nutrition Examination Survey (NHANES III, 1988–1994). Kidney stone history was self-reported during the survey. Vital status and causes of death during follow-up were ascertained via the National Death Index through December 31, 2019. Weighted Cox proportional hazards models estimated hazard ratios (HRs) for the association between kidney stone history and all-cause, cardiovascular, cancer, and renal mortality. Models were progressively adjusted for demographic, socioeconomic, and clinical variables to account for confounding factors.

Results

The final analytic sample comprised 19,578 participants (weighted kidney stone prevalence = 5.3%) with 420,947 person-years of follow-up (range: 0–31 years). Stone formers were older than non-stone formers (mean age 54 vs. 43 years) with a higher prevalence of comorbidities. In the unadjusted model, kidney stone history was associated with increased all-cause mortality risk (HR = 1.82; 95% CI 1.63–2.03). However, this association was attenuated in the fully adjusted model (HR = 0.89; 95% CI 0.79–1.01). No significant differences were observed between groups for cardiovascular (HR = 0.87; 95% CI 0.73–1.03), cancer (HR = 1.01; 95% CI 0.74–1.37), or renal mortality (HR = 0.99; 95% CI 0.31–3.16) in fully adjusted models.

Conclusion

In this nationally representative cohort of US adults, a history of kidney stones was not associated with an increased risk of all-cause or cause-specific mortality after adjustment for confounders.