Mesenchymal stem cell-derived exosomes in renal ischemia–reperfusion injury: a new therapeutic strategy

期刊论文
发表日期：

2024年11月9日

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Bo Zhao,
Zhenwang Zhang,
Xiying Guo,
Xiufen Liu,
Min Lei,
Shuang Guo,
Qing Yao,
Feixue Zhang,
Tie Peng,
Aimei Liu,
Botao Jiang,
Dan Zhu

摘要

Renal ischemia–reperfusion injury (RIRI) is a serious kidney condition that causes significant damage due to lack of blood flow. This injury leads to oxidative stress and inflammation, which can cause acute tubular necrosis and kidney failure. Stem cell-derived exosomes, small vesicles released by stem cells, have shown promise in treating RIRI. Mesenchymal stem cells (MSCs) have been used to mitigate RIRI, and their exosomes have been found to play a crucial role in repairing damaged tissues. This review explores the key roles of exosomes from different sources of MSCs in RIRI, the potential of MSC-derived exosomes in treating this disease, and future research directions.