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<p>This study investigated the effects of Coenzyme Q10 (CoQ10) oral administration on biochemical, immunological, microbiological, and productive parameters in sheep. Forty Barki ewes (3.5 ± 0.6 years; 47.5 ± 0.5&#xa0;kg; 91–96 days of gestation) were randomly assigned to a control group (standard diet) and a treatment group (standard diet + 2&#xa0;mg CoQ10 /kg BW). The experiment was conducted from late gestation through four weeks postpartum. CoQ10 administration increased serum total protein (5.49 vs. 5.01&#xa0;g/dL) and globulin (3.00 vs. 2.49&#xa0;g/dL) at parturition (<i>p</i> &lt; 0.01), along with higher immunoglobulin A (IgA) (92.60 vs. 74.20 ng/mL) and glutathione peroxidase (GPx) activity (28.55 vs. 19.15 U/mL). In lambs of CoQ10-treated ewes, total protein (5.41 vs. 4.52&#xa0;g/dL), IgA (137.10 vs. 88.01 ng/mL), and total antioxidant capacity (TAC) (43.96 vs. 32.11 mM/L) were higher (<i>p</i> &lt; 0.05). Colostrum and milk from treated ewes showed higher solids-not-fat (15.41 vs. 12.32%, <i>p</i> &lt; 0.01) and fat content (up to 7.7 vs. 5.7%, <i>p</i> &lt; 0.01), with consistently higher immunoglobulins and reduced microbial incidence. Milk yield was higher in treated ewes, with a significant increase at week 4. Lambs of CoQ10-treated ewes had consistently higher body weight at all measured time points (<i>p</i> &lt; 0.05). In conclusion, periparturient CoQ10 administration enhanced antioxidant status, immune-related parameters, milk quality, and growth performance. These findings support CoQ10 as a potential management strategy to alleviate periparturient stress and improve productivity in sheep production systems. Further studies are needed to optimize dosage and evaluate long-term effects under commercial conditions.</p>

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Periparturient coenzyme Q10 administration: effects on immunity, milk quality, and growth performance in sheep

  • 期刊论文

  • 发表日期：

    2026年7月22日

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  • Mohammed Hamed Eldawy,
  • Ismail Abdelraouf Elnady,
  • Emad Mohammed Elken,
  • Hanaa A.E. Asfour,
  • El-Shaimaa N. Mehany,
  • Mahmoud Gamal Rashad,
  • Haney Samir,
  • Hossam R. El-Sherbiny,
  • Nadia Hamdi Fahim

摘要

This study investigated the effects of Coenzyme Q10 (CoQ10) oral administration on biochemical, immunological, microbiological, and productive parameters in sheep. Forty Barki ewes (3.5 ± 0.6 years; 47.5 ± 0.5 kg; 91–96 days of gestation) were randomly assigned to a control group (standard diet) and a treatment group (standard diet + 2 mg CoQ10 /kg BW). The experiment was conducted from late gestation through four weeks postpartum. CoQ10 administration increased serum total protein (5.49 vs. 5.01 g/dL) and globulin (3.00 vs. 2.49 g/dL) at parturition (p < 0.01), along with higher immunoglobulin A (IgA) (92.60 vs. 74.20 ng/mL) and glutathione peroxidase (GPx) activity (28.55 vs. 19.15 U/mL). In lambs of CoQ10-treated ewes, total protein (5.41 vs. 4.52 g/dL), IgA (137.10 vs. 88.01 ng/mL), and total antioxidant capacity (TAC) (43.96 vs. 32.11 mM/L) were higher (p < 0.05). Colostrum and milk from treated ewes showed higher solids-not-fat (15.41 vs. 12.32%, p < 0.01) and fat content (up to 7.7 vs. 5.7%, p < 0.01), with consistently higher immunoglobulins and reduced microbial incidence. Milk yield was higher in treated ewes, with a significant increase at week 4. Lambs of CoQ10-treated ewes had consistently higher body weight at all measured time points (p < 0.05). In conclusion, periparturient CoQ10 administration enhanced antioxidant status, immune-related parameters, milk quality, and growth performance. These findings support CoQ10 as a potential management strategy to alleviate periparturient stress and improve productivity in sheep production systems. Further studies are needed to optimize dosage and evaluate long-term effects under commercial conditions.