<p>Historically <i>Amblyomma hebraeum</i> has been found in the north-eastern part of South Africa and along the coastal belt stretching to the Eastern Cape area. A change already noted in the past 20 years has been the increase in distribution area in the Eastern Cape, which now includes a larger inland area. It has been postulated that climate change has brought about a change in the distribution of <i>A. hebraeum</i> and subsequently, its potential tick-borne pathogens (TBP), <i>Ehrlichia ruminantium</i> and <i>Rickettsia africae</i>, in South Africa and that the effects of climate change may lead to further distribution changes in future. Habitat suitability modelling using Maxent software demonstrated that the distribution of <i>A. hebraeum</i> has altered compared to previous predictions done 15 years ago and that by the year 2065, most of the central and eastern parts of South Africa are predicted to have a high habitat suitability index for its presence. This indicates that the potential presence of diseases caused by <i>E. ruminantium</i> and <i>R. africae</i> would have to be considered in these previously unaffected areas when animals or humans show signs of illness. This expanded distribution of <i>A. hebraeum</i> and its TBP could have a substantial health and economic impact in South Africa.</p>