<p>The aim of this study was to determine whether the socio-productive characteristics of Sheep Production Units (SPU) in the State of Mexico are related to the level of animal welfare (AW) of their animals. A survey was conducted with 37 sheep producers to identify their profiles, sheep management practices, and understanding of aspects of AW. The second level of the AWIN Protocol was used to measure the health status of 710 sheep by assessing body condition, mucosal color, fleece and/or hair cleanliness and loss, fecal soiling, and tail length, using a semi-quantitative intensity scale. A hierarchical agglomerative clustering analysis was performed to integrate similarities in clusters (CLs). Four CLs were defined based on differences in socio-productive characteristics, management, and facilities, none of which affected the sheep’s health status. The relationship between the CL and the data collected in the survey and from the animals was determined. In conclusion, there was no evidence of a relationship between the socio-productive characteristics of the SPUs in the State of Mexico and the indicators used to assess the AW of their sheep, except for fleece and/or hair cleanliness. The SPUs with the worst punctuation in this indicator were those where animals were confined, where facilities differed, and where sheep producers were less experienced.</p>