<p>Discarded cocoa seed meal (DCSM), a byproduct of cocoa processing, has potential as an unconventional feed resource. This study evaluated the effects of DCSM on growth performance, haematology, lipid profile, and liver function of mixed-bred rabbits reared in the humid tropics. Over an eight-week feeding trial, forty-eight mixed-bred male and female rabbits (initial mean weight: 1.45 ± 0.42&#xa0;kg) were randomly allocated to four dietary levels of DCSM treatments (G): G₁ (0%), G₂ (15%), G₃ (30%), and G₄ (45%), in a 4 × 2 factorial arrangement within a completely randomized design (three replicates of four rabbits each). At the end of the trial, blood samples were collected from four rabbits per treatment group. Results showed that feed intake declined progressively with increasing levels of DCSM. Significant differences (<i>p</i> &lt; 0.05) were recorded for male and female rabbit on feed intake, feed conversion ratio, and mortality. Increasing dietary DCSM caused significant (<i>p</i> &lt; 0.05) elevations in white blood cells, red blood cells, haemoglobin (Hb), and packed cell volume. Male rabbits exhibited higher (<i>p</i> &lt; 0.05) Hb, mean corpuscular volume, and mean corpuscular haemoglobin concentration than females. Lipid profiles varied significantly (<i>p</i> &lt; 0.05) across treatments, with G₂ showing higher total cholesterol, triglycerides, and low-density lipoprotein compared to G₁ (control), G₃, and G₄. Liver metabolites showed marked effects (<i>p</i> &lt; 0.05) on total and direct bilirubin, with G₄ presenting higher values than other groups. Albumin and alanine aminotransferase concentrations were also higher (<i>p</i> &lt; 0.05) in males. The findings indicate that DCSM alters haematological indices, lipid metabolism, and liver metabolites but should be included at low levels (15–30%) in rabbit diets to minimize adverse effects.</p>