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<p>Small ruminants, especially goats, are highly valued for their meat, milk and fibre. The introduction of prolific breeds can boost productivity, offer farmers additional income and contribute to food security. This study aimed to examine the polymorphism of eight fragments of different genes related to reproductive efficiency in fifty Rohilkhandi goats using PCR-RFLP and to analyse the association of these variants with various reproductive traits. The gene fragments analysed were FecB, FecX<sup>G</sup>, FecX<sup>I</sup>, FecX<sup>B</sup>, FecX<sup>H</sup>, GDF9, MSTN and IGF1. Genetic polymorphism was detected in the MSTN and IGF1 gene fragments out of the eight analysed. The reproductive traits evaluated included the age of the doe at 1st kidding, average kidding interval, average litter size, kidding per year, kids per year and weight of doe at 1st kidding etc., with a mean value of 546.98 ± 10.52 days, 316.65 ± 6.21 days, 1.32 ± 0.05, 1.17 ± 0.02, 1.54 ± 0.06 and 16.09 ± 0.15&#xa0;kg, respectively. The mixed-model analysis revealed that MSTN genotypes significantly influenced (<i>p</i> &lt; 0.05) ADK, BWDK, KPY and approached significance (<i>p</i> = 0.05) for LS, while IGF1 genotypes significantly affected (<i>p</i> &lt; 0.05) traits ADK and BWDK. These findings suggest that polymorphisms in the MSTN and IGF1 genes may directly or indirectly influence reproductive performance in Rohilkhandi goats. This first genomic investigation in the breed provides preliminary evidence of such associations and underscores the need for larger, multi-breed studies to validate these results and identify reliable molecular markers for use in marker-assisted selection to improve fecundity and productivity in indigenous goats.</p>

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Exploring genetic polymorphisms and their association with reproductive traits in Rohilkhandi goats

  • 期刊论文

  • 发表日期：

    2025年11月26日

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  • Nitish Gaitri,
  • Subodh Kumar,
  • Pushpendra Kumar,
  • Amit Kumar,
  • Hari Om Pandey,
  • Roshni Chand

摘要

Small ruminants, especially goats, are highly valued for their meat, milk and fibre. The introduction of prolific breeds can boost productivity, offer farmers additional income and contribute to food security. This study aimed to examine the polymorphism of eight fragments of different genes related to reproductive efficiency in fifty Rohilkhandi goats using PCR-RFLP and to analyse the association of these variants with various reproductive traits. The gene fragments analysed were FecB, FecXG, FecXI, FecXB, FecXH, GDF9, MSTN and IGF1. Genetic polymorphism was detected in the MSTN and IGF1 gene fragments out of the eight analysed. The reproductive traits evaluated included the age of the doe at 1st kidding, average kidding interval, average litter size, kidding per year, kids per year and weight of doe at 1st kidding etc., with a mean value of 546.98 ± 10.52 days, 316.65 ± 6.21 days, 1.32 ± 0.05, 1.17 ± 0.02, 1.54 ± 0.06 and 16.09 ± 0.15 kg, respectively. The mixed-model analysis revealed that MSTN genotypes significantly influenced (p < 0.05) ADK, BWDK, KPY and approached significance (p = 0.05) for LS, while IGF1 genotypes significantly affected (p < 0.05) traits ADK and BWDK. These findings suggest that polymorphisms in the MSTN and IGF1 genes may directly or indirectly influence reproductive performance in Rohilkhandi goats. This first genomic investigation in the breed provides preliminary evidence of such associations and underscores the need for larger, multi-breed studies to validate these results and identify reliable molecular markers for use in marker-assisted selection to improve fecundity and productivity in indigenous goats.