<p>This study aimed to evaluate the effects of including a blend of acid and alkaline proteases in broiler diets on performance parameters, nutrient digestibility, and intestinal morphology. A total of 180 chicks were divided into the following groups: Positive Control (PC), Negative Control (with 8% reduction in crude protein—NC), and NC + blend proteases (BP) at 125&#xa0;g/t (BP125). On days 1 and 21, the broilers and the feed were weighed for performance analysis, and a digestibility test was performed from days 17 to 21. The highest body weight and weight gain were observed in the broilers of the PC and BP125 groups (<i>P</i> = 0.001). The addition of protease to the diet (BP125) increased the ADC of crude protein, which was statistically similar to the PC group; both were higher than those observed in the NC group. We observed that the BP125 group had more excellent digestibility of the amino acids of serine (<i>P</i> = 0.032), threonine (<i>P</i> = 0.050), valine (<i>P</i> = 0.042), methionine (<i>P</i> = 0.050), cysteine (<i>P</i> = 0.012), arginine (<i>P</i> &lt; 0.001) and tryptophan (<i>P</i> = 0.05) when compared to NC; but similar to PC group. It was also possible to observe a better villus and crypt ratio when protease was used in a low-protein diet (<i>P</i> = 0.05). These findings suggest that protease supplementation improves nutrient utilization and performance in low-protein diets.</p>