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<p>The coat color of the swamp buffalo is commonly dark gray, while the white coat color variant, which may have potential heat stress advantages, is also present in some Asian countries, including Vietnam. This study analyzed the most likely candidate genes, <i>ASIP</i> and <i>TYR</i>, responsible for the white coat color of Vietnamese native buffaloes. We found that LINE1 insertion in <i>ASIP</i>, a mutation previously reported in white swamp buffalo from other Asian countries, was exclusively found in white Vietnamese buffalo. Moreover, significantly higher expression of <i>ASIP</i> was confirmed in the hair follicles of white buffalo. On the other hand, no variants associated with the white phenotype were found in <i>TYR.</i> These findings indicate that the LINE1 insertion in <i>ASIP</i> is responsible for the white coat color in Vietnamese native buffalo, and that provides a crucial step towards their utilization and improved productivity in Vietnam.</p>

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White coat color in Vietnamese native buffalo is attributed to the LINE1 insertion in ASIP

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月11日

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  • Thuy Thanh Nguyen,
  • Quan Viet Le,
  • Van Huu Nguyen,
  • Hai Thanh Duong,
  • Takehito Tsuji

摘要

The coat color of the swamp buffalo is commonly dark gray, while the white coat color variant, which may have potential heat stress advantages, is also present in some Asian countries, including Vietnam. This study analyzed the most likely candidate genes, ASIP and TYR, responsible for the white coat color of Vietnamese native buffaloes. We found that LINE1 insertion in ASIP, a mutation previously reported in white swamp buffalo from other Asian countries, was exclusively found in white Vietnamese buffalo. Moreover, significantly higher expression of ASIP was confirmed in the hair follicles of white buffalo. On the other hand, no variants associated with the white phenotype were found in TYR. These findings indicate that the LINE1 insertion in ASIP is responsible for the white coat color in Vietnamese native buffalo, and that provides a crucial step towards their utilization and improved productivity in Vietnam.