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<p>Over the past two decades, several outbreaks of viruses with epidemic and pandemic potential have been witnessed globally, such as severe acute respiratory syndrome (SARS) coronaviruses, middle east respiratory syndrome (MERS), Ebola, and new strains of Influenza. Among these, the recent pandemic SARS-CoV-2 has scourged over 6.8 million people worldwide. Although several vaccines and antiviral medications have been developed, their efficacy has become limited due to the emergence of new SARS-CoV-2 strains (&gt; 4000 variants) hindering their prompt deployment. Hence, it is necessary to develop safe and potent antiviral drugs, which is the need of the hour. Recently the applications of nanomaterials (NMs) have revolutionized medical approaches toward the diagnosis and treatment of SARS-CoV-2. The compendium of potent antiviral nanostructures was accumulated from various public databases including PubMed, ScienceDirect, Google Scholar, and ResearchGate. This article extensively discusses the multifaceted novel antiviral strategies and mechanisms of action of nanomaterials as novel antiviral agents for the attenuation of SARS-CoV-2 infections and pathogenesis using diverse mechanisms. Thus, it can be believed that these unique nanomaterials will pave the way to combat the fatal SARS-CoV-2 soon.</p> Graphical Abstract <p></p>

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A Review on Nanomaterials Based Antiviral Strategies Targeting SARS CoV-2 Replication and Infection Mechanisms

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • B. Uma Reddy,
  • Monica K. J. Nidhi,
  • B. Sreevani,
  • Arunkumar Lagashetty

摘要

Over the past two decades, several outbreaks of viruses with epidemic and pandemic potential have been witnessed globally, such as severe acute respiratory syndrome (SARS) coronaviruses, middle east respiratory syndrome (MERS), Ebola, and new strains of Influenza. Among these, the recent pandemic SARS-CoV-2 has scourged over 6.8 million people worldwide. Although several vaccines and antiviral medications have been developed, their efficacy has become limited due to the emergence of new SARS-CoV-2 strains (> 4000 variants) hindering their prompt deployment. Hence, it is necessary to develop safe and potent antiviral drugs, which is the need of the hour. Recently the applications of nanomaterials (NMs) have revolutionized medical approaches toward the diagnosis and treatment of SARS-CoV-2. The compendium of potent antiviral nanostructures was accumulated from various public databases including PubMed, ScienceDirect, Google Scholar, and ResearchGate. This article extensively discusses the multifaceted novel antiviral strategies and mechanisms of action of nanomaterials as novel antiviral agents for the attenuation of SARS-CoV-2 infections and pathogenesis using diverse mechanisms. Thus, it can be believed that these unique nanomaterials will pave the way to combat the fatal SARS-CoV-2 soon.

Graphical Abstract