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<p>This study reports the hydrothermal synthesis, comprehensive characterization, and catalytic evaluation of zirconia nanoparticles with various phases for chemoselective reduction of α-keto esters &amp; amides. These nanoparticles exhibited remarkable catalytic activity in highly chemoselective reduction reactions in which monoclinic zirconia NP’s show excellent efficiency, particularly in the reduction of α-keto esters and amides utilizing NaBH<sub>4</sub> as the reductant and methanol/ethanol as environmentally benign solvents. A significant advancement is demonstrated through the achievement of 83–99% conversions for α-hydroxy esters and α-hydroxy amides in a remarkably short time frame of 20–25&#xa0;min. Furthermore, the ZrO<sub>2</sub> nano-catalyst demonstrates remarkable reusability, maintaining catalytic activity through five consecutive cycles without significant decline. A combination of FE-SEM, XRD, EDX-elemental mapping, FTIR, BET analysis, and Ammonia TPD techniques was employed to investigate the morphology, thermal stability, crystal structure, and surface acidity of fresh ZrO<sub>2</sub> NP’s. The TPD results reveal that M-ZrO<sub>2</sub> exhibits superior acidic properties compared to T-ZrO<sub>2</sub>.</p> Graphical Abstract <p></p>

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Zirconium Oxide Nanoparticles Catalysed Chemo Selective Reduction of α-Keto Esters and Amides

  • 期刊论文

  • 发表日期：

    2025年6月10日

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  • Anuprita A. Mathkar,
  • Bhalchandra M. Bhanage

摘要

This study reports the hydrothermal synthesis, comprehensive characterization, and catalytic evaluation of zirconia nanoparticles with various phases for chemoselective reduction of α-keto esters & amides. These nanoparticles exhibited remarkable catalytic activity in highly chemoselective reduction reactions in which monoclinic zirconia NP’s show excellent efficiency, particularly in the reduction of α-keto esters and amides utilizing NaBH4 as the reductant and methanol/ethanol as environmentally benign solvents. A significant advancement is demonstrated through the achievement of 83–99% conversions for α-hydroxy esters and α-hydroxy amides in a remarkably short time frame of 20–25 min. Furthermore, the ZrO2 nano-catalyst demonstrates remarkable reusability, maintaining catalytic activity through five consecutive cycles without significant decline. A combination of FE-SEM, XRD, EDX-elemental mapping, FTIR, BET analysis, and Ammonia TPD techniques was employed to investigate the morphology, thermal stability, crystal structure, and surface acidity of fresh ZrO2 NP’s. The TPD results reveal that M-ZrO2 exhibits superior acidic properties compared to T-ZrO2.

Graphical Abstract