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<p>In this research, the hybrid compound (KL11) Mo<sub>12</sub>O<sub>40</sub>Si·2(C<sub>4</sub>H<sub>13</sub>N<sub>5</sub>)·2(H<sub>2</sub>O) obtained from the reaction of the Keggin polyoxometalate (K) and the organic compound metformin (L11), was characterised by the MALDI-TOF, FTIR, and UV-vis spectroscopic techniques. The single crystals of the hybrid compound (KL11) were obtained by recrystallisation them from an aqueous medium, and its molecular nature was investigated by single crystal X-ray method. It was found that the hybrid (KL11) compound crystallise in the triclinic system with a <i>P</i><sub>¯</sub>1 space group. In order to investigate the oxidation-reduction properties of hybrid (KL11) compound, its electrochemical properties were investigated by cyclic voltammetry in the potential range of -2.0 to + 2.0&#xa0;V and scan rates of 10–100 mVs⁻¹. The thermal properties of hybrid (KL11) compound were investigated by thermal methods in the temperature range of 40–970&#xa0;°C. The cytotoxicity of the organic-inorganic hybrid compound KL11 against cis-platin-resistant mesothelioma cells was investigated. DNA cleavage assays of the hybrid compound KL11 revealed no significant degradation of plasmid DNA, even at doses similar to those used for positive controls. The emission and excitation spectra of the hybrid compound were shifted to shorter wavelengths compared to metformin.</p>

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X-ray structure, electrochemical, biological activity and thermal properties of Keggin POM based hybrid compound

  • 期刊论文

  • 发表日期：

    2026年8月4日

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  • Eyüp Akgün

摘要

In this research, the hybrid compound (KL11) Mo12O40Si·2(C4H13N5)·2(H2O) obtained from the reaction of the Keggin polyoxometalate (K) and the organic compound metformin (L11), was characterised by the MALDI-TOF, FTIR, and UV-vis spectroscopic techniques. The single crystals of the hybrid compound (KL11) were obtained by recrystallisation them from an aqueous medium, and its molecular nature was investigated by single crystal X-ray method. It was found that the hybrid (KL11) compound crystallise in the triclinic system with a P¯1 space group. In order to investigate the oxidation-reduction properties of hybrid (KL11) compound, its electrochemical properties were investigated by cyclic voltammetry in the potential range of -2.0 to + 2.0 V and scan rates of 10–100 mVs⁻¹. The thermal properties of hybrid (KL11) compound were investigated by thermal methods in the temperature range of 40–970 °C. The cytotoxicity of the organic-inorganic hybrid compound KL11 against cis-platin-resistant mesothelioma cells was investigated. DNA cleavage assays of the hybrid compound KL11 revealed no significant degradation of plasmid DNA, even at doses similar to those used for positive controls. The emission and excitation spectra of the hybrid compound were shifted to shorter wavelengths compared to metformin.