Two novel benzotriazole Cu(II) complexes: synthesis, structure and antidiabetic activity
摘要
Two novel benzotriazole Cu(II) complexes, [Cu(bmem)(CH3O)Cl]n (1) and [Cu(btmt)(H2O)(SO4)]2 (2), were synthesized and characterized using 1-(benzotriazole-1-methyl)-1-(2-ethylimidazole) (bmem) and 1-(benzotriazole-1-methyl)-1-triazole (btmt) as ligands. X-ray single crystal diffraction analysis indicates that complex 1 forms a one-dimensional chain structure of a double-nuclear copper unit, while complex 2 forms a discrete binuclear copper unit. Their antidiabetic activities were thoroughly investigated. The antidiabetic activity assays demonstrated that both complexes exhibited inhibitory effects against α-amylase and α-glycosidase enzymes. Specifically, complex 1 showed IC50 values of 2.92 × 10− 3 M for α-amylase and 2.39 × 10− 6 M for α-glycosidase, while complex 2 exhibited IC50 values of 1.89 × 10− 3 M and 1.63 × 10− 6 M, respectively, with complex 2 displaying a stronger inhibitory effect overall. Furthermore, to evaluate the effects of complexes 1 and 2 on glucose metabolism, we treated insulin-resistant (IR) HepG2 cells with each complex. The results demonstrated that complexes 1 and 2 enhanced glucose uptake by 1.20-fold and 1.32-fold, respectively, compared to the untreated control.