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<p>Aminocarbonylation reactions represent a powerful synthetic strategy for constructing amide bonds—key structural motifs in pharmaceuticals, agrochemicals, and functional materials. In recent years, magnetic nanocatalysts have gained significant attention as efficient, sustainable, and reusable platforms for promoting these transformations. This review highlights recent developments in the design, application, and mechanistic understanding of magnetic nanocatalysts employed in aminocarbonylation reactions. Emphasis is placed on systems based on palladium, nickel, and copper nanoparticles supported on magnetically responsive materials such as Fe₃O₄, which enable facile catalyst separation and reuse via external magnetic fields. The role of surface functionalization, core–shell architectures, and ligand modification in enhancing catalytic performance is discussed in detail. In addition, we address key challenges, including metal leaching, deactivation, and scalability, and explore the growing interest in carbon monoxide surrogates for safer, greener aminocarbonylation. Outlooks on the integration of magnetic nanocatalysts with continuous-flow technologies and the potential of machine learning in catalyst design are also presented. Overall, this review underscores the significant potential of magnetic nanocatalysts in developing efficient, scalable, and environmentally responsible aminocarbonylation protocols for modern synthetic chemistry.</p> Graphical abstract <p></p>

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Magnetically recoverable catalysts in aminocarbonylation reactions: a sustainable strategy for synthesis of amides

  • 期刊论文

  • 发表日期：

    2025年11月11日

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  • Rana Said,
  • Radwan Ali,
  • Ahmed M. Amshawee,
  • M. M. Rekha,
  • Shaker Al-Hasnaawei,
  • Subhashree Ray,
  • Amrita Pal,
  • Renu Sharma,
  • Mosstafa Kazemi

摘要

Aminocarbonylation reactions represent a powerful synthetic strategy for constructing amide bonds—key structural motifs in pharmaceuticals, agrochemicals, and functional materials. In recent years, magnetic nanocatalysts have gained significant attention as efficient, sustainable, and reusable platforms for promoting these transformations. This review highlights recent developments in the design, application, and mechanistic understanding of magnetic nanocatalysts employed in aminocarbonylation reactions. Emphasis is placed on systems based on palladium, nickel, and copper nanoparticles supported on magnetically responsive materials such as Fe₃O₄, which enable facile catalyst separation and reuse via external magnetic fields. The role of surface functionalization, core–shell architectures, and ligand modification in enhancing catalytic performance is discussed in detail. In addition, we address key challenges, including metal leaching, deactivation, and scalability, and explore the growing interest in carbon monoxide surrogates for safer, greener aminocarbonylation. Outlooks on the integration of magnetic nanocatalysts with continuous-flow technologies and the potential of machine learning in catalyst design are also presented. Overall, this review underscores the significant potential of magnetic nanocatalysts in developing efficient, scalable, and environmentally responsible aminocarbonylation protocols for modern synthetic chemistry.

Graphical abstract