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<p>A series of novel zinc(II) halide complexes with the versatile twisted, non-classical scorpionate ligand, bis((5-methyl-1,3,4-thiadiazol-2-yl)thio)methane (CH<sub>2</sub>(S-tdzMe)<sub>2</sub>) (1), have been synthesized and characterized. The ligand (1) reacts with ZnX<sub>2</sub> (X = Br, Cl, I) in a 1:1 molar ratio to afford the complexes [Zn(CH<sub>2</sub>(S-tdzMe)<sub>2</sub>)X<sub>2</sub>] (X = I (2), Br (3), Cl (4)). These complexes, along with the ligand, were characterized by elemental analysis, FT-IR, HRMS, UV–Vis, and multinuclear NMR spectroscopy. Single crystal X-ray diffraction studies of the ligand (1) and complex (4) revealed a tetrahedral geometry around the zinc(II) ion with the ligand coordinating in a κ2N-fashion. Preliminary interaction studies with bovine serum albumin (BSA) using fluorescence spectroscopy suggest potential protein-binding capability.</p>

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Zn(II) complexes of a novel twisted carbon-centred non-classical scorpionate derived from bis(thiadiazole)alkanes (CH2(S-tdzMe)2): synthesis, structural characterization and protein interaction studies

  • 期刊论文

  • 发表日期：

    2025年9月8日

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  • Saravana Kumar Moorthy,
  • Sarathi Natarajan,
  • Ashok Kumar Saravana Loganathan,
  • Anandaram Sreekanth

摘要

A series of novel zinc(II) halide complexes with the versatile twisted, non-classical scorpionate ligand, bis((5-methyl-1,3,4-thiadiazol-2-yl)thio)methane (CH2(S-tdzMe)2) (1), have been synthesized and characterized. The ligand (1) reacts with ZnX2 (X = Br, Cl, I) in a 1:1 molar ratio to afford the complexes [Zn(CH2(S-tdzMe)2)X2] (X = I (2), Br (3), Cl (4)). These complexes, along with the ligand, were characterized by elemental analysis, FT-IR, HRMS, UV–Vis, and multinuclear NMR spectroscopy. Single crystal X-ray diffraction studies of the ligand (1) and complex (4) revealed a tetrahedral geometry around the zinc(II) ion with the ligand coordinating in a κ2N-fashion. Preliminary interaction studies with bovine serum albumin (BSA) using fluorescence spectroscopy suggest potential protein-binding capability.