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<p>Two manganese complexes formulated as [Mn(L<sup>1</sup>)<sub>2</sub>] (Mn1) and [Mn (L<sup>2</sup>)<sub>2</sub>] (Mn2) (HL<sup>1</sup> = 2-acetylpyrazine N<sup>4</sup>-methylthiosemicarbazone, HL<sup>2</sup> = 2-acetylpyrazine N<sup>4</sup>-dimethylthiosemicarbazone) have been synthesized and characterized, and the molecular structure of complexes 1 and 2 have been determined by single-crystal X-ray diffraction. 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging test results suggest that HL<sup>2</sup> and its manganese complexes could exhibit efficient antioxidant abilities. The in vitro antibacterial properties of HL<sup>1</sup> and HL<sup>2</sup>, also the two complexes, have been evaluated against <i>E. coli</i> and <i>S. aureus</i>, also Ampicillin-resistant <i>E. coli</i> and Kanamycin-resistant <i>E. coli</i>. The results indicated that HL<sup>2</sup> and Mn2 can present much more efficient antibacterial activity than Mn1 and HL<sup>1</sup>. The in vitro cytotoxicity assay results showed that Mn2 exhibited appreciable cytotoxic activity against HCT-116 cells and HepG2 cells, and it also displayed efficient cancer selectivity. Upon comparing these results, it is indicated that minor differences in the structures of the two ligands had a significant impact on the biological activities of both the ligands and their manganese complexes.</p>

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Synthesis, characterization, antioxidant, and biological activity of manganese (II) complexes based on 2-acetylpyrazine thiosemicarbazones

  • 期刊论文

  • 发表日期：

    2025年2月17日

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  • Jin Wang,
  • Zhi-Meng Zhang,
  • Chun Wang,
  • Wenjie Shi,
  • Ming-Xue Li,
  • Guo-Ping Zu

摘要

Two manganese complexes formulated as [Mn(L1)2] (Mn1) and [Mn (L2)2] (Mn2) (HL1 = 2-acetylpyrazine N4-methylthiosemicarbazone, HL2 = 2-acetylpyrazine N4-dimethylthiosemicarbazone) have been synthesized and characterized, and the molecular structure of complexes 1 and 2 have been determined by single-crystal X-ray diffraction. 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging test results suggest that HL2 and its manganese complexes could exhibit efficient antioxidant abilities. The in vitro antibacterial properties of HL1 and HL2, also the two complexes, have been evaluated against E. coli and S. aureus, also Ampicillin-resistant E. coli and Kanamycin-resistant E. coli. The results indicated that HL2 and Mn2 can present much more efficient antibacterial activity than Mn1 and HL1. The in vitro cytotoxicity assay results showed that Mn2 exhibited appreciable cytotoxic activity against HCT-116 cells and HepG2 cells, and it also displayed efficient cancer selectivity. Upon comparing these results, it is indicated that minor differences in the structures of the two ligands had a significant impact on the biological activities of both the ligands and their manganese complexes.