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<p>Plant cell cultures and hairy roots are highly promising tools for sustainable production of important secondary metabolites without destroying the natural habitat of the plants. Multiple factors influence their accumulation in cultured cells. Generation of mutant cells by gamma irradiation, selection of stable cell lines or hairy root clumps that produce secondary plant products in long-term cultures and understanding the role of arabinogalactans in maintaining cell aggregate sizes are crucial for accelerating and optimizing secondary metabolite accumulation. Elicitors like nanoparticles and cyclodextrins not only boost the secondary metabolite synthesis, but also facilitate their release into medium allowing easier product recovery especially for hydrophobic compounds. Such a strategy prevents feedback regulation of the product. Hence, these tools are becoming determining factors for sustainable production of secondary metabolites. This review focusses on selected, but under explored strategies for augmenting secondary metabolite accumulation.</p>

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Induced mutations, cell line selections, nanoparticles and cyclodextrins for improving secondary metabolite accumulation in vitro

  • 期刊论文

  • 发表日期：

    2026年2月14日

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  • P. B. Kavi Kishor,
  • Rupasree Mukhopadhyay,
  • P. Hima Kumari,
  • Swaroopa Patil,
  • Bangaru Naidu Thaddi,
  • Deekshitha Kosaraju,
  • M. S. L. Sunita,
  • S. Anil Kumar

摘要

Plant cell cultures and hairy roots are highly promising tools for sustainable production of important secondary metabolites without destroying the natural habitat of the plants. Multiple factors influence their accumulation in cultured cells. Generation of mutant cells by gamma irradiation, selection of stable cell lines or hairy root clumps that produce secondary plant products in long-term cultures and understanding the role of arabinogalactans in maintaining cell aggregate sizes are crucial for accelerating and optimizing secondary metabolite accumulation. Elicitors like nanoparticles and cyclodextrins not only boost the secondary metabolite synthesis, but also facilitate their release into medium allowing easier product recovery especially for hydrophobic compounds. Such a strategy prevents feedback regulation of the product. Hence, these tools are becoming determining factors for sustainable production of secondary metabolites. This review focusses on selected, but under explored strategies for augmenting secondary metabolite accumulation.