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<p>Venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism, is a major cause of cardiovascular morbidity and mortality. Although perioperative VTE is well described, the prognostic significance of a prior history of VTE in patients undergoing transcatheter valve interventions remains unclear. We conducted a retrospective cohort study using the National Inpatient Sample from 2016 to 2020. Hospitalizations for elective isolated TAVR and TMVR were identified using ICD-10 procedure codes. Patients were stratified by the presence or absence of documented prior VTE. Multivariable regression models were used to evaluate associations between prior VTE and in-hospital mortality, length of stay, and hospitalization costs. Analyses were performed separately for TAVR and TMVR cohorts and adjusted for demographic, clinical, and hospital-level covariates. A total of 295,795 TAVR and 5,145 TMVR hospitalizations were identified. Prior VTE was present in 1.1% of TAVR and 2.8% of TMVR patients. Patients with prior VTE had significantly higher in-hospital mortality compared with those without VTE (TAVR: 11% vs. 2%; TMVR: 8% vs. 1.5%). After multivariable adjustment, prior VTE remained independently associated with higher odds of in-hospital mortality (TAVR odds ratio 5.96, 95% CI 4.31–8.22; TMVR odds ratio 5.58, 95% CI 1.67–18.59). Prior VTE was also associated with longer hospitalization and higher costs. Prior VTE is associated with higher in-hospital mortality, longer hospitalizations, and greater healthcare resource utilization among patients undergoing transcatheter valve interventions and may identify a high-risk subgroup.</p>

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Prior venous thromboembolism and in-hospital mortality after transcatheter valve interventions: a national analysis

  • 期刊论文

  • 发表日期：

    2026年7月14日

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  • Vaishvik Patel,
  • Maria Acosta,
  • Oluwakorede Akele,
  • Mariana Valdez Thomas,
  • Diana Lund,
  • Mauricio Sosa Quintanilla,
  • Christian Siochi

摘要

Venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism, is a major cause of cardiovascular morbidity and mortality. Although perioperative VTE is well described, the prognostic significance of a prior history of VTE in patients undergoing transcatheter valve interventions remains unclear. We conducted a retrospective cohort study using the National Inpatient Sample from 2016 to 2020. Hospitalizations for elective isolated TAVR and TMVR were identified using ICD-10 procedure codes. Patients were stratified by the presence or absence of documented prior VTE. Multivariable regression models were used to evaluate associations between prior VTE and in-hospital mortality, length of stay, and hospitalization costs. Analyses were performed separately for TAVR and TMVR cohorts and adjusted for demographic, clinical, and hospital-level covariates. A total of 295,795 TAVR and 5,145 TMVR hospitalizations were identified. Prior VTE was present in 1.1% of TAVR and 2.8% of TMVR patients. Patients with prior VTE had significantly higher in-hospital mortality compared with those without VTE (TAVR: 11% vs. 2%; TMVR: 8% vs. 1.5%). After multivariable adjustment, prior VTE remained independently associated with higher odds of in-hospital mortality (TAVR odds ratio 5.96, 95% CI 4.31–8.22; TMVR odds ratio 5.58, 95% CI 1.67–18.59). Prior VTE was also associated with longer hospitalization and higher costs. Prior VTE is associated with higher in-hospital mortality, longer hospitalizations, and greater healthcare resource utilization among patients undergoing transcatheter valve interventions and may identify a high-risk subgroup.