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<p>Patients with peripheral artery disease undergoing lower extremity revascularization remain at high risk for cardiovascular events despite intervention. This retrospective analysis of 289 participants examined the relationship between pre-procedural bleeding history and post-procedural outcomes using a modified International Society on Thrombosis and Haemostasis bleeding assessment tool. After median 18-month follow-up, participants with significant bleeding history experienced lower risk of major adverse cardiovascular events (18.4% versus 30.6%, <i>p</i> = 0.034) and mortality (13.6% versus 24.2%, <i>p</i> = 0.047). An inverse exposure-outcome relationship was observed between bleeding severity and outcomes. Bleeding history may identify patients at lower risk for thrombotic complications.</p><?pagebreak??> Graphical abstract <p>Methods and key findings</p> <p></p>

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Bleeding history is associated with lower risk of cardiovascular events in a cohort undergoing lower extremity revascularization

  • 期刊论文

  • 发表日期：

    2026年5月29日

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  • David J. Bresnahan,
  • Yuhe Xia,
  • Nathaniel R. Smilowitz,
  • Elliot Luttrell-Williams,
  • Lila Murphy,
  • Tessa J. Barrett,
  • Caron B. Rockman,
  • Jeffrey S. Berger

摘要

Patients with peripheral artery disease undergoing lower extremity revascularization remain at high risk for cardiovascular events despite intervention. This retrospective analysis of 289 participants examined the relationship between pre-procedural bleeding history and post-procedural outcomes using a modified International Society on Thrombosis and Haemostasis bleeding assessment tool. After median 18-month follow-up, participants with significant bleeding history experienced lower risk of major adverse cardiovascular events (18.4% versus 30.6%, p = 0.034) and mortality (13.6% versus 24.2%, p = 0.047). An inverse exposure-outcome relationship was observed between bleeding severity and outcomes. Bleeding history may identify patients at lower risk for thrombotic complications.

Graphical abstract

Methods and key findings