Impact of Glucose and Urea on the Aggregation and Thermodynamic Characterictics of Micellization in Sodium Dodecyl Sulfate and Ofloxacin Mixture

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发表日期：

2026年7月4日

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A. Srivastava,
R. Nayak,
N. Srivastava

摘要

Micellization in a solution of sodium dodecyl sulfate (SDS) containing the antibiotic ofloxacin (OFX) in the presence of glucose or urea in the temperature range of 293-323 K has been studied by conductometry. It is shown that the critical micelle concentration (CMC) of SDS increases in the presence of OFX. The addition of urea increases the CMC in the SDS-OFX mixture, while in the presence of glucose the CMC decreases. The thermodynamic parameters of micellization, ∆ ${G}_{\text{m}}^{0}$ $G_{m}^{0}$ , ∆ ${H}_{\text{m}}^{0}$ $H_{m}^{0}$ , and ∆ ${S}_{\text{m}}^{0}$ $S_{m}^{0}$ , have been determined and it is proved that the SDS-OFX mixture undergoes spontaneous micellization both in pure water and in an aqueous solution of glucose or urea.