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<p>It has been shown that a series of indenyl-hydrazono-thiazole derivatives could be obtained in quantitative yields by a mechanochemical method without the use of solvents. According to the results of the study by NMR and electron spectroscopy it was found that the tautomeric amino-form of the thiazole ring in indenyl-hydrazono-thiazolidin-4-one was more stable compared to the imino form. Thiazole derivatives containing chlorophenyl and nitrophenyl groups in the thiazole ring possessed significant activity against S. Aureus.</p>

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Mechanochemical Synthesis of Indenyl-Hydrazono-Thiazole Derivatives and Their Antibacterial Properties

  • 期刊论文

  • 发表日期：

    2025年3月1日

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  • D. Gautam,
  • R. P. Chaudhary

摘要

It has been shown that a series of indenyl-hydrazono-thiazole derivatives could be obtained in quantitative yields by a mechanochemical method without the use of solvents. According to the results of the study by NMR and electron spectroscopy it was found that the tautomeric amino-form of the thiazole ring in indenyl-hydrazono-thiazolidin-4-one was more stable compared to the imino form. Thiazole derivatives containing chlorophenyl and nitrophenyl groups in the thiazole ring possessed significant activity against S. Aureus.