Influence of Composition and Structure of Charge Transfer Complexes of Tioconazole on Their Spectral Properties and Anticancer Activity
摘要
It is shown that interaction of electron donor tioconazole (TCZ) with π acceptors chloroanilic acid, 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, and picric acid leads to formation of the charge transfer complexes. The obtained complexes are characterized by spectral methods, and specific features of their structure are revealed by DFT. It is found that such complexes possess cytotoxic activity against breast cancer line (MCF-7), and their efficiency on IC50 criterion exceeds the efficiency of the individual TCZ.