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Crystallization of chiral thiourea derivatives of 1-phenylethylamine: transfer of stable motifs from racemic to homochiral environment

  • Lyubov V. Frantsuzova,
  • Daria P. Gerasimova,
  • Kirill E. Metlushka,
  • Elena K. Badeeva,
  • Kristina A. Nikitina,
  • Ruzal G. Zinnatullin,
  • Kamil A. Ivshin,
  • Olga N. Kataeva,
  • Olga A. Lodochnikova

摘要

In a series of three chiral thioureas with a 1-phenylethylamine fragment, none of the homochiral samples forms “true chiral” hydrogen-bonded motifs in the crystal, but forms dimers or chains with local symmetry from the interacting fragments, consistent with the racemic crystal pattern.