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<p>Surface plasmon resonance (SPR)-based sensors have emerged as powerful tools for fast, label-free detection of refractive index variations associated with physical, chemical, and biological analytes. In this work, a theoretical analysis of three-layer metallic fiber optic SPR sensor configurations is conducted for the detection of skin and blood cancers. Various combinations of gold, silver, copper, and aluminum layers are evaluated using the Kretschmann configuration with the wavelength interrogation method. Performance parameters such as sensitivity, detection accuracy, and figure of merit are analyzed to identify optimal designs. The highest sensitivity of 5700&#xa0;nm/RIU is observed for Au/Ag/Au, Au/Al/Au, and Au/Cu/Au configurations in skin cancer detection, while a maximum sensitivity of 7300&#xa0;nm/RIU is achieved for Au/Ag/Au, Al/Au/Al, and Au/Cu/Au configurations in blood cancer detection. The Cu/Ag/Cu configuration yields the highest FOM values of 717.74 RIU⁻¹ and 777.78 RIU⁻¹ for skin and blood cancer detection, respectively. The results demonstrate that three-layer metallic structures significantly improve sensing performance compared to single-layer and bimetallic sensors, with certain configurations achieving high sensitivity and FOM, indicating strong potential for early cancer diagnostics.</p> Graphical Abstract <p></p>

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Three-Layer Metallic Fiber Optic SPR Sensors for Skin and Blood Cancer Detection

  • 期刊论文

  • 发表日期：

    2026年7月1日

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  • R. Seena,
  • Shiny Paul,
  • V. R. Sudheer

摘要

Surface plasmon resonance (SPR)-based sensors have emerged as powerful tools for fast, label-free detection of refractive index variations associated with physical, chemical, and biological analytes. In this work, a theoretical analysis of three-layer metallic fiber optic SPR sensor configurations is conducted for the detection of skin and blood cancers. Various combinations of gold, silver, copper, and aluminum layers are evaluated using the Kretschmann configuration with the wavelength interrogation method. Performance parameters such as sensitivity, detection accuracy, and figure of merit are analyzed to identify optimal designs. The highest sensitivity of 5700 nm/RIU is observed for Au/Ag/Au, Au/Al/Au, and Au/Cu/Au configurations in skin cancer detection, while a maximum sensitivity of 7300 nm/RIU is achieved for Au/Ag/Au, Al/Au/Al, and Au/Cu/Au configurations in blood cancer detection. The Cu/Ag/Cu configuration yields the highest FOM values of 717.74 RIU⁻¹ and 777.78 RIU⁻¹ for skin and blood cancer detection, respectively. The results demonstrate that three-layer metallic structures significantly improve sensing performance compared to single-layer and bimetallic sensors, with certain configurations achieving high sensitivity and FOM, indicating strong potential for early cancer diagnostics.

Graphical Abstract