<p>A notable sensitivity of 538.23&#xa0;deg/RIU for the detection of chemical substances is reported using the surface plasmon resonance (SPR) technique with the N-FK51a+Al₂O₃+Cu+SiO₂+BP configuration. The sensing performance of this innovative configuration was evaluated numerically using analytes including 2-methoxyethanol, n-butyl chloride, methyl isoamyl ketone, cyclopentane, and tetrahydrofuran, with refractive indices ranging from 1.4021 to 1.4072. In this configuration, copper offers enhanced plasmonic excitation relative to conventional metals, while the SiO₂ layer facilitates improved interfacial compatibility and reduces propagation losses. Black phosphorus (BP), due to its anisotropic and adjustable electrical properties, serves as the primary sensing layer, facilitating enhanced light-matter interaction and exceptional refractive index sensitivity. The incorporation of copper renders the device substantially more cost-effective than traditional gold (Au) or silver (Ag)-based SPR sensors, thereby potentially reducing diagnostic expenses significantly. Furthermore, the Al₂O₃ layer offers enhanced interfacial adhesion, superior chemical stability, and durable surface protection, thereby ensuring long-term structural integrity. The results underscore the exceptional performance of this innovative design, exhibiting a sensitivity of 538.23&#xa0;deg/RIU, a quality factor of 194.95 RIU^-1, a figure of merit of 187.36, and a minimal reflectance of merely 0.030. The TMM, FEM, and FDTD simulations, as well as the sensor parameters, were investigated in this study. This work demonstrates the outstanding potential of a hybrid SPR-based sensing platform to achieve robust as well as highly sensitive detection for multi-analyte organic chemicals, which has notable implications for advanced environmental or industrial monitoring.</p> Graphical Abstract <p></p>