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<p>A novel quadruple-band metamaterial-based biosensor is systematically designed and analyzed for early-stage cancer detection. The proposed sensor features a tri-layer metal–dielectric–metal structure (Au–dielectric–Au), optimized to achieve strong electric and magnetic field confinement at multiple resonance frequencies. The design demonstrates high absorption, with peak values reaching approximately 0.9 at four distinct resonances: 1.87 THz, 2.42 THz, 3.05 THz, and 3.60 THz. The biosensor exhibits high refractive index sensitivity, making it highly suitable for detecting cancerous cells. The potential of the design is evaluated for sensing various cancer cell types, including Basal, Cervical, Breast, and Jurkat cells, demonstrating its robustness and versatility. The average sensitivity values for these cell types are 481&#xa0;GHz/RIU at 1.87 THz, 1009.2&#xa0;GHz/RIU at 2.42 THz, 1392.5&#xa0;GHz/RIU at 3.05 THz, and 1774.2&#xa0;GHz/RIU at 3.60 THz, respectively. A comparative study with the state-of-the-art THz biosensors confirms the superior performance of the proposed design in terms of both sensitivity and quality factor. Additionally, the sensor’s compact footprint and simplified fabrication process enhance its potential for seamless integration into real-time biomedical diagnostic systems. These results highlight the effectiveness of the developed biosensor for early cancer diagnostics and suggest its broader applicability in clinical and biomedical sensing platforms.</p>

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Multi-band Metamaterial Biosensor for Early Cancer Detection

  • 期刊论文

  • 发表日期：

    2026年4月10日

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  • Mahmoud Maree E. Tammam,
  • Tamer A. Ali,
  • Essam M. A. Elkaramany,
  • S. S. A. Obayya,
  • Mohamed Farhat O. Hameed

摘要

A novel quadruple-band metamaterial-based biosensor is systematically designed and analyzed for early-stage cancer detection. The proposed sensor features a tri-layer metal–dielectric–metal structure (Au–dielectric–Au), optimized to achieve strong electric and magnetic field confinement at multiple resonance frequencies. The design demonstrates high absorption, with peak values reaching approximately 0.9 at four distinct resonances: 1.87 THz, 2.42 THz, 3.05 THz, and 3.60 THz. The biosensor exhibits high refractive index sensitivity, making it highly suitable for detecting cancerous cells. The potential of the design is evaluated for sensing various cancer cell types, including Basal, Cervical, Breast, and Jurkat cells, demonstrating its robustness and versatility. The average sensitivity values for these cell types are 481 GHz/RIU at 1.87 THz, 1009.2 GHz/RIU at 2.42 THz, 1392.5 GHz/RIU at 3.05 THz, and 1774.2 GHz/RIU at 3.60 THz, respectively. A comparative study with the state-of-the-art THz biosensors confirms the superior performance of the proposed design in terms of both sensitivity and quality factor. Additionally, the sensor’s compact footprint and simplified fabrication process enhance its potential for seamless integration into real-time biomedical diagnostic systems. These results highlight the effectiveness of the developed biosensor for early cancer diagnostics and suggest its broader applicability in clinical and biomedical sensing platforms.