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<p>Early detection of cancer is a significant need to reduce the death rates from this disease across the globe. Here, we propose a novel surface plasmon resonance (SPR) sensor that employs a BK7 prism as a coupler with magnesium hydride (MgH<sub>2</sub>) and cadmium selenide (CdSe) materials to detect different types of cancerous cells. This MATLAB simulation-based study employs the transfer matrix method (TMM) for calculating reflectance. Angle interrogation was employed to detect resonance shifts corresponding to different cancer cells, including Basal, HeLa, Jurkat, PC-12, MDA-MB-231, and MCF-7, with respect to their refractive indices (RIs). The key characteristics, such as sensitivity, quality factor, detection accuracy, and full width at half maximum, were computed through which we analysed the proposed structure’s performance. The peak value of sensitivity observed was 220.14 degree/RIU for MCF-7 cells, with a peak quality factor of 24.21 (1/RIU), which demonstrates its potential for early-stage cancerous cell detection.</p>

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Efficient SPR-Based Cancer Cell Detection Using MgH₂ and CdSe Layers with Angular Interrogation Approach

  • 期刊论文

  • 发表日期：

    2026年1月6日

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  • Thangjam Iboyaima Singh,
  • Bhishma Karki,
  • Ashish R. Tanna

摘要

Early detection of cancer is a significant need to reduce the death rates from this disease across the globe. Here, we propose a novel surface plasmon resonance (SPR) sensor that employs a BK7 prism as a coupler with magnesium hydride (MgH2) and cadmium selenide (CdSe) materials to detect different types of cancerous cells. This MATLAB simulation-based study employs the transfer matrix method (TMM) for calculating reflectance. Angle interrogation was employed to detect resonance shifts corresponding to different cancer cells, including Basal, HeLa, Jurkat, PC-12, MDA-MB-231, and MCF-7, with respect to their refractive indices (RIs). The key characteristics, such as sensitivity, quality factor, detection accuracy, and full width at half maximum, were computed through which we analysed the proposed structure’s performance. The peak value of sensitivity observed was 220.14 degree/RIU for MCF-7 cells, with a peak quality factor of 24.21 (1/RIU), which demonstrates its potential for early-stage cancerous cell detection.