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<p>On-chip waveguide-based biosensor has been designed for label-free detection of cancerous cells. The proposed biosensor design has a SiN core with equal height trenches on a SiO<sub>2</sub> substrate. The finite element method with perfectly matched layer boundary conditions is used to estimate the spectral variation of confinement loss for six types of cancer cells, including Basal, Jurkat, Hela, PC-12, MDA-MB-231, and MCF-7. When analytes come into contact with the sensing surface of the sensor, the refractive index of the surface is varied, and correspondingly, there is a wavelength shift. The maximum sensitivity is found to be 2666.67&#xa0;nm/RIU for PC-12 (adrenal gland cancer) with a high figure of merit of 65.33 (RIU)<sup>−1</sup>. The proposed design presents the potential for detecting various cancer cells, demonstrating a distinct resonant dip for both normal and cancerous cells when operated with commercially available laser sources with a central wavelength of 2.0&#xa0;μm.</p>

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Performance Analysis of the Trench-Assisted Waveguide for Cancer Cell Detection

  • 期刊论文

  • 发表日期：

    2025年11月8日

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  • Akshita Bansal,
  • Neena Jaggi,
  • Than Singh Saini

摘要

On-chip waveguide-based biosensor has been designed for label-free detection of cancerous cells. The proposed biosensor design has a SiN core with equal height trenches on a SiO2 substrate. The finite element method with perfectly matched layer boundary conditions is used to estimate the spectral variation of confinement loss for six types of cancer cells, including Basal, Jurkat, Hela, PC-12, MDA-MB-231, and MCF-7. When analytes come into contact with the sensing surface of the sensor, the refractive index of the surface is varied, and correspondingly, there is a wavelength shift. The maximum sensitivity is found to be 2666.67 nm/RIU for PC-12 (adrenal gland cancer) with a high figure of merit of 65.33 (RIU)−1. The proposed design presents the potential for detecting various cancer cells, demonstrating a distinct resonant dip for both normal and cancerous cells when operated with commercially available laser sources with a central wavelength of 2.0 μm.