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<p>Cancer remains a significant threat to the healthy life of people worldwide. Cervical, breast, and blood cancers are reported to be among the major concerns. Early-stage diagnosis is critically important, as it significantly enhances the effectiveness of treatment and improves patient survival outcomes. Optical sensors based on surface plasmon resonance (SPR) are best suited for the real-time and accurate detection of cancer. Three hybrid nanostructured SPR sensor configurations, viz. Au/TiO<sub>2</sub>/Al/MXene, Ag/TiO<sub>2</sub>/Al/MXene, and Cu/TiO<sub>2</sub>/Al/MXene, have been proposed for the detection of cervical cancer, breast cancer, and blood cancer. The performance parameters were analyzed using MATLAB. Higher sensitivities with better FOM of 8400&#xa0;nm/RIU, 10,000&#xa0;nm/RIU, 10,600&#xa0;nm/RIU, and 8050&#xa0;nm/RIU, respectively, have been observed for cervical cancer, breast cancer type I, breast cancer type II, and blood cancer based on theoretical modeling. The proposed sensors work well across a wide range of refractive index values, making them versatile biosensing platforms suitable for detecting various types of cancers.</p>

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Kretschmann Configuration Based SPR Biosensor For Cancer Detection

  • 期刊论文

  • 发表日期：

    2025年9月23日

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  • R. Seena,
  • Shiny Paul,
  • V. R. Sudheer

摘要

Cancer remains a significant threat to the healthy life of people worldwide. Cervical, breast, and blood cancers are reported to be among the major concerns. Early-stage diagnosis is critically important, as it significantly enhances the effectiveness of treatment and improves patient survival outcomes. Optical sensors based on surface plasmon resonance (SPR) are best suited for the real-time and accurate detection of cancer. Three hybrid nanostructured SPR sensor configurations, viz. Au/TiO2/Al/MXene, Ag/TiO2/Al/MXene, and Cu/TiO2/Al/MXene, have been proposed for the detection of cervical cancer, breast cancer, and blood cancer. The performance parameters were analyzed using MATLAB. Higher sensitivities with better FOM of 8400 nm/RIU, 10,000 nm/RIU, 10,600 nm/RIU, and 8050 nm/RIU, respectively, have been observed for cervical cancer, breast cancer type I, breast cancer type II, and blood cancer based on theoretical modeling. The proposed sensors work well across a wide range of refractive index values, making them versatile biosensing platforms suitable for detecting various types of cancers.