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<p>The phenomenon of surface plasmon resonance (SPR) continues to offer more advantages compared to other approaches in the field of biosensors. Over the years, different materials and configurations have been proposed to improve the performance of SPR-based biosensors. In this work, we present an SPR biosensor based on a metal–insulator–metal structure with silver (Ag) and a gold–silver (Au–Ag) alloy. Our approach is based on a prism-coupled Kretschmann configuration and the transfer matrix method. Theoretical simulation shows that our proposed biosensor produces a very narrow reflectivity dip and a larger field enhancement at the sensing interface. Looking at its performance metrics, this biosensor has a sensitivity value of 120°/RIU, a figure of merit value of 240/RIU, and a higher sensing medium penetration depth value of 255.32&#xa0;nm. We also present an experimental feasibility section outlining steps that can be taken to realize this biosensor in real life. The potential limitations and challenges in the fabrication process are discussed. Additionally, external factors that can affect the performance of the biosensor are also examined.</p>

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Investigating the Role of a Gold–Silver Alloy in a Metal–Insulator–Metal SPR Biosensor

  • 期刊论文

  • 发表日期：

    2025年6月10日

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  • Innocent Kadaleka Phiri,
  • Mohssin Zekriti

摘要

The phenomenon of surface plasmon resonance (SPR) continues to offer more advantages compared to other approaches in the field of biosensors. Over the years, different materials and configurations have been proposed to improve the performance of SPR-based biosensors. In this work, we present an SPR biosensor based on a metal–insulator–metal structure with silver (Ag) and a gold–silver (Au–Ag) alloy. Our approach is based on a prism-coupled Kretschmann configuration and the transfer matrix method. Theoretical simulation shows that our proposed biosensor produces a very narrow reflectivity dip and a larger field enhancement at the sensing interface. Looking at its performance metrics, this biosensor has a sensitivity value of 120°/RIU, a figure of merit value of 240/RIU, and a higher sensing medium penetration depth value of 255.32 nm. We also present an experimental feasibility section outlining steps that can be taken to realize this biosensor in real life. The potential limitations and challenges in the fabrication process are discussed. Additionally, external factors that can affect the performance of the biosensor are also examined.