<p>The Earth’s ionosphere involves long-standing plasma problems, such as instabilities and nonlinearity. The global ionospheric layers contain multi-scale irregular structures characterized by plasma density fluctuations and random permittivity. These ionospheric structures can degrade or even disrupt trans-ionospheric radio signals from satellite systems, and also disturb HF communications by altering the ionospheric properties. Ionospheric disturbance is one of the major problems in space weather, due to its unique role in the solar-terrestrial causal chain. To address these, the artificial ionospheric modification, achieved through the release of chemicals, enables a deeper understanding of physical mechanisms, provides a means to cope with ionospheric scintillations, and allows for the generation of artificial plasma clouds to tailor radio wave propagation. This paper analyzes the challenges, opportunities, and issues in the frontiers of artificially tailored radio wave propagation via ionospheric chemical releases. Some suggestions are also put forward for future experiments.</p>