<p>Parents of children with developmental disabilities often feel apprehensive about guiding their children through puberty, sexuality, and sexual development. Given the limited sex education training available to them, this study explored which sexual development topics parents considered important for training. As part of a larger project on parental knowledge of their children’s sexuality, 46 parents in Ghana completed several surveys, including one on desired training topics. The findings revealed a strong demand for education, with 98% of parents wanting to learn how to protect their children from sexual abuse. Additionally, high percentages of parents were interested in communicating effectively with children about sexuality (93.5%), understanding their roles as sexuality educators (93.3%), and comprehending the human body, reproduction, and pregnancy (93.5%). These results offer clear guidelines for developing comprehensive sex education training programs tailored for parents of children with developmental disabilities. Such training is crucial and would empower parents to explain, educate, and support their children in navigating their sexuality and ensuring their safety during adolescence.</p>