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<p>Hydrogel films based on corn starch, polyvinyl alcohol, and sodium carboxymethylcellulose and loaded with sodium diclofenac (1 and 2.5 wt.% relative to weight of the polymer) were obtained, and their properties were evaluated. It was found that at the mass ratio of polymers of 40 : 40 : 20, physicomechanical properties of the films correspond to those of commercial wound dressings of similar type by means of swelling degree, vapor permeability, and mechanical parameters. Within the framework of the electrostatic potential for intermolecular complexation (EPIC) model, it was shown that the most energetically favorable is the non-covalent interaction of diclofenac with carboxymethylcellulose moieties in the hydrogel network. The kinetics for diclofenac release from the polymeric matrix in various biorelevant environments was investigated. It was found that the release is prolonged in all cases and obeys the Fick’s laws for the diffusion. A mathematical description for the release profile revealed that controlled release of the therapeutic agent from the wound dressing can be achieved upon optimizations of the cross-linking density.</p>

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Hydrogel polysaccharide compositions comprising diclofenac as promising materials for wound therapy

  • 期刊论文

  • 发表日期：

    2026年3月1日

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  • T. V. Kryuk,
  • T. G. Tyurina,
  • T. I. Zavyazkina,
  • O. M. Zarechnaya,
  • A. N. Malaya,
  • G. P. Goncharuk

摘要

Hydrogel films based on corn starch, polyvinyl alcohol, and sodium carboxymethylcellulose and loaded with sodium diclofenac (1 and 2.5 wt.% relative to weight of the polymer) were obtained, and their properties were evaluated. It was found that at the mass ratio of polymers of 40 : 40 : 20, physicomechanical properties of the films correspond to those of commercial wound dressings of similar type by means of swelling degree, vapor permeability, and mechanical parameters. Within the framework of the electrostatic potential for intermolecular complexation (EPIC) model, it was shown that the most energetically favorable is the non-covalent interaction of diclofenac with carboxymethylcellulose moieties in the hydrogel network. The kinetics for diclofenac release from the polymeric matrix in various biorelevant environments was investigated. It was found that the release is prolonged in all cases and obeys the Fick’s laws for the diffusion. A mathematical description for the release profile revealed that controlled release of the therapeutic agent from the wound dressing can be achieved upon optimizations of the cross-linking density.