Scholarlink

<p>The introduction of an ionol fragment at the N(1) position of substituted isatins leads to formation of compounds capable of effectively inhibiting pharmacologically important serine esterases, <i>viz.</i>, acetylcholinesterase and carboxylesterase, and possessing the antioxidant activity. An inverse correlation between the antioxidant activity in the ABTS test and the calculated values of the Δ<sub>HOMO-LUMO</sub> (<i>r</i><sup>2</sup> = 0.69, <i>n</i> = 11, <i>p</i> = 0.0015) is demonstrated. The electrochemical properties of the synthesized compounds were studied by cyclic voltammetry.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Esterase profile, antioxidant activity, and electrochemical properties of sterically hindered phenolic isatin derivatives

  • 期刊论文

  • 发表日期：

    2026年3月1日

查看全文
  • A. V. Bogdanov,
  • G. F. Makhaeva,
  • N. P. Boltneva,
  • N. V. Kovaleva,
  • E. V. Rudakova,
  • A. V. Sukhov,
  • A. R. Khamatgalimov,
  • D. G. Yakhvarov

摘要

The introduction of an ionol fragment at the N(1) position of substituted isatins leads to formation of compounds capable of effectively inhibiting pharmacologically important serine esterases, viz., acetylcholinesterase and carboxylesterase, and possessing the antioxidant activity. An inverse correlation between the antioxidant activity in the ABTS test and the calculated values of the ΔHOMO-LUMO (r2 = 0.69, n = 11, p = 0.0015) is demonstrated. The electrochemical properties of the synthesized compounds were studied by cyclic voltammetry.