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<p>Polymer compositions of hydrophobic methyl pheophorbide <i>a</i> (MPP), a promising photosensitizer for photodynamic therapy of oncological and microbial diseases, has been developed by encapsulating into structures of new amphiphilic copolymers of <i>N</i>-isopropylacrylamide (NIPA) with triethylene glycol dimethacrylate. Their absorption in phosphate-buffered saline solutions was studied using UV/visible spectroscopy, and the sizes of polymer particles “loaded” with a dye were estimated by dynamic light scattering. Images of the polymer particle—dye structures were obtained by transmission electron microscopy. Quantum chemical modeling of possible structures of MPP—NIPA copolymers was carried out, and a possibility of formation of hydrogen bonds between different groups and atoms of the dye and monomer units of copolymers and residues of chain transfer agents built into polymer chains was shown.</p>

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Water-soluble polymer compositions of methyl pheophorbide a based on thermosensitive copolymers of N-isopropylacrylamide with triethylene glycol dimethacrylate

  • 期刊论文

  • 发表日期：

    2026年2月1日

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  • I. V. Ulyanov,
  • N. S. Emel’yanova,
  • I. I. Khodos,
  • S. V. Kurmaz

摘要

Polymer compositions of hydrophobic methyl pheophorbide a (MPP), a promising photosensitizer for photodynamic therapy of oncological and microbial diseases, has been developed by encapsulating into structures of new amphiphilic copolymers of N-isopropylacrylamide (NIPA) with triethylene glycol dimethacrylate. Their absorption in phosphate-buffered saline solutions was studied using UV/visible spectroscopy, and the sizes of polymer particles “loaded” with a dye were estimated by dynamic light scattering. Images of the polymer particle—dye structures were obtained by transmission electron microscopy. Quantum chemical modeling of possible structures of MPP—NIPA copolymers was carried out, and a possibility of formation of hydrogen bonds between different groups and atoms of the dye and monomer units of copolymers and residues of chain transfer agents built into polymer chains was shown.