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<p>Ester derivatives of benzoic and salicylic acids with potential antibacterial and antifungal activity were synthesized. A derivative of the natural biocide thymol, ethanolamine, and octan-1-ol were used as a hydroxy-containing component in the preparation of the esters. Empty and loaded with synthesized compounds liposome dispersions were obtained using ultrasonic dispersion. The loading of the liposome systems was assessed using UV spectroscopy; the percentage of incorporation of synthesized compounds was up to 25 wt.%. Preliminary studies of the biological activity of liposomal forms of conjugates <i>in vitro</i> were conducted against <i>Yarrovia lipolitica</i> W29 and <i>Bacillus subtilis</i> 4419. The liposomal forms of conjugates were found to inhibit the growth of bacterial colonies 10–100 times more efficiently than the parent biocides and free conjugates.</p>

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Derivatives of benzoic, salicylic acids, thymol, and liposomes based on them: synthesis and evaluation of biological activity

  • 期刊论文

  • 发表日期：

    2026年1月1日

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  • E. G. Shubenkova,
  • T. A. Yarkova,
  • S. A. Lipanova,
  • V. A. Sokhraneva,
  • K. A. Kirdina,
  • A. V. Rozumiy,
  • N. N. Gessler,
  • I. D. Tikhomirov,
  • N. V. Groza

摘要

Ester derivatives of benzoic and salicylic acids with potential antibacterial and antifungal activity were synthesized. A derivative of the natural biocide thymol, ethanolamine, and octan-1-ol were used as a hydroxy-containing component in the preparation of the esters. Empty and loaded with synthesized compounds liposome dispersions were obtained using ultrasonic dispersion. The loading of the liposome systems was assessed using UV spectroscopy; the percentage of incorporation of synthesized compounds was up to 25 wt.%. Preliminary studies of the biological activity of liposomal forms of conjugates in vitro were conducted against Yarrovia lipolitica W29 and Bacillus subtilis 4419. The liposomal forms of conjugates were found to inhibit the growth of bacterial colonies 10–100 times more efficiently than the parent biocides and free conjugates.