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<p>Convenient syntheses of functionalized mono- and bisphosphorus-substituted methylamines and their derivatives, containing P—C—N and P—C(N)—P units, based on aminoacetals and their analogs have been developed. Dialkoxyphosphines, diethyl pivaloylphosphonite, diethyl phosphite, or trivalent phosphorus acid trimethylsilyl esters react with mono- and bis(alkoxymethyl)amines in the presence of effective catalysts, zinc chloride or boron trifluoride etherate, to afford new target products in high yields. The resulting substances, functionalized mono- and bisphosphorus-containing methylamines, are structural analogs of amino carboxylic acids and natural pyrophosphates and are of interest as promising biologically active substances, water-soluble polydentate ligands, and effective extractants.</p>

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Synthesis of functionalized mono- and bisphosphorus-containing methylamines based on aminoacetals and their analogs

  • 期刊论文

  • 发表日期：

    2026年1月1日

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  • Yu. N. Bubnov,
  • A. A. Prishchenko,
  • M. V. Livantsov,
  • O. P. Novikova,
  • L. I. Livantsova,
  • S. V. Baranin

摘要

Convenient syntheses of functionalized mono- and bisphosphorus-substituted methylamines and their derivatives, containing P—C—N and P—C(N)—P units, based on aminoacetals and their analogs have been developed. Dialkoxyphosphines, diethyl pivaloylphosphonite, diethyl phosphite, or trivalent phosphorus acid trimethylsilyl esters react with mono- and bis(alkoxymethyl)amines in the presence of effective catalysts, zinc chloride or boron trifluoride etherate, to afford new target products in high yields. The resulting substances, functionalized mono- and bisphosphorus-containing methylamines, are structural analogs of amino carboxylic acids and natural pyrophosphates and are of interest as promising biologically active substances, water-soluble polydentate ligands, and effective extractants.