Scholarlink

<p>Spiroheterocyclic compounds, (3′<i>R</i>*,4′ <i>S</i>*)-3′-(het)aryl-3,5,5′-trioxospiro[pyrazolidine-4,2′-pyrrolidine]-4′-carbohydrazides, were synthesized by the reaction of diastereopure trimethyl (3<i>R</i>*,4<i>S</i>*)-1-acetyl-4-(het)aryl-2-pyrrolidone-3,5,5-tricarboxylates with hydrazine hydrate. The structures of the synthesized compounds were confirmed by spectral methods and X-ray diffraction analysis. Some of the new compounds were found to exhibit anxiolytic and antidepressant activity.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Synthesis, structure, and biological activity of 3,5,5′-trioxospiro[pyrazolidine-4,2′-pyrrolidine]-4′-carbohydrazides

  • 期刊论文

  • 发表日期：

    2026年1月1日

查看全文
  • N. V. Gorodnicheva,
  • O. S. Vasil’eva,
  • E. S. Ostroglyadov,
  • R. I. Baichurin,
  • A. V. Fel’gendler,
  • I. A. Litvinov,
  • S. V. Makarenko,
  • D. A. Bakulin,
  • N. S. Bolokhov,
  • V. E. Pustynnikov,
  • I. N. Tyurenkov

摘要

Spiroheterocyclic compounds, (3′R*,4′ S*)-3′-(het)aryl-3,5,5′-trioxospiro[pyrazolidine-4,2′-pyrrolidine]-4′-carbohydrazides, were synthesized by the reaction of diastereopure trimethyl (3R*,4S*)-1-acetyl-4-(het)aryl-2-pyrrolidone-3,5,5-tricarboxylates with hydrazine hydrate. The structures of the synthesized compounds were confirmed by spectral methods and X-ray diffraction analysis. Some of the new compounds were found to exhibit anxiolytic and antidepressant activity.