Scholarlink

<p>Ethyl 12-chlorosulfodehydroabietate was used in the first synthesis of hydroxysulfonamides containing monoethanolamine and phenylalaninol fragments in 98% and 95% yields, respectively. <i>p</i>-Toluenesulfonyl derivatives of these hydroxysulfonamides were found to react with potassium thioacetate to be converted to thioacetates. However, they underwent quantitative conversion to disulfides in the presence of trace amounts of pyridine. Both thioacetates and disulfides were oxidized with chlorine dioxide to sulfonyl chlorides in 90–96% yields.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Pyridine-mediated synthesis of dehydroabietane-derived disulfides and their oxidation with chlorine dioxide to sulfonyl chlorides

  • 期刊论文

  • 发表日期：

    2025年12月1日

查看全文
  • E. S. Izmest’ev,
  • S. V. Pestova,
  • D. V. Petukhov,
  • S. A. Rubtsova

摘要

Ethyl 12-chlorosulfodehydroabietate was used in the first synthesis of hydroxysulfonamides containing monoethanolamine and phenylalaninol fragments in 98% and 95% yields, respectively. p-Toluenesulfonyl derivatives of these hydroxysulfonamides were found to react with potassium thioacetate to be converted to thioacetates. However, they underwent quantitative conversion to disulfides in the presence of trace amounts of pyridine. Both thioacetates and disulfides were oxidized with chlorine dioxide to sulfonyl chlorides in 90–96% yields.