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<p>Surface functionalization of organic electrochemical transistors (OECTs) is an urgent challenge in the development of biosensors. In this work, we propose a new method to functionalize the poly(3,4-ethylenedioxythiophene)—poly(styrene sulfonate) (PEDOT:PSS) active layer of OECTs with the bioreceptor layer. Namely, the surface of the PEDOT:PSS layer was modified with nonpolar hexyl groups. A Langmuir layer consisting of a siloxane dimer of [1]benzothieno[3,2-<i>b</i>][1]benzothiophene (BTBT) and its biotinylated derivative was used as the receptor layer. It was found that the receptor layer does not affect the mechanism of OECT operation and allows for transistor surface coverage with the recognition elements. The specificity of the developed biosensor is provided by the biotin-streptavidin interaction. A DNA aptamer specific to the influenza A virus was used as the recognition element, while the inactivated influenza B virus, the Newcastle disease virus, and an allantoic fluid were used as non-specific controls.</p>

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Functionalization of the poly(3,4-ethylenedioxythiophene):poly-(styrene sulfonate) active layer of the organic electrochemical transistors to create biosensors

  • 期刊论文

  • 发表日期：

    2025年11月1日

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  • Ya. O. Titova,
  • E. Yu. Poimanova,
  • A. A. Trul,
  • P. N. Karaman,
  • A. K. Keshek,
  • E. V. Agina,
  • S. A. Ponomarenko

摘要

Surface functionalization of organic electrochemical transistors (OECTs) is an urgent challenge in the development of biosensors. In this work, we propose a new method to functionalize the poly(3,4-ethylenedioxythiophene)—poly(styrene sulfonate) (PEDOT:PSS) active layer of OECTs with the bioreceptor layer. Namely, the surface of the PEDOT:PSS layer was modified with nonpolar hexyl groups. A Langmuir layer consisting of a siloxane dimer of [1]benzothieno[3,2-b][1]benzothiophene (BTBT) and its biotinylated derivative was used as the receptor layer. It was found that the receptor layer does not affect the mechanism of OECT operation and allows for transistor surface coverage with the recognition elements. The specificity of the developed biosensor is provided by the biotin-streptavidin interaction. A DNA aptamer specific to the influenza A virus was used as the recognition element, while the inactivated influenza B virus, the Newcastle disease virus, and an allantoic fluid were used as non-specific controls.