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<p>A new synthetic approach was developed to prepare α-methylpyridines and their cyclopentene-fused analogs <i>via</i> the condensation of 2-bromopropiophenones with carboxylic acid hydrazides to form 1,2,4-triazines followed by their transformation by the Boger reaction. The synthesis can be accomplished by a one-pot procedure. It was demonstrated that the α-methyl group in the pyridine moiety can be further modified.</p>

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New synthetic approach to α-methylpyridines

  • 期刊论文

  • 发表日期：

    2025年11月1日

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  • M. I. Valieva,
  • Ya. K. Shtaitz,
  • A. P. Krinochkin,
  • D. S. Kopchuk,
  • A. V. Rybakova,
  • A. V. Golovina,
  • K. D. Krasnoperova,
  • I. L. Nikonov,
  • P. A. Slepukhin,
  • M. N. Strukova,
  • G. V. Zyryanov

摘要

A new synthetic approach was developed to prepare α-methylpyridines and their cyclopentene-fused analogs via the condensation of 2-bromopropiophenones with carboxylic acid hydrazides to form 1,2,4-triazines followed by their transformation by the Boger reaction. The synthesis can be accomplished by a one-pot procedure. It was demonstrated that the α-methyl group in the pyridine moiety can be further modified.